Zebrafish-Based Screening Models for the Identification of Anti-Metastatic Drugs.

Molecules 2020 May 21;25(10). Epub 2020 May 21.

Tsuruoka Metabolomics Laboratory, National Cancer Center, Mizukami 246-2, Kakuganji, Tsuruoka, Yamagata 975-0052, Japan.

Metastasis, a leading contributor to the morbidity of cancer patients, occurs through a multi-step process: invasion, intravasation, extravasation, colonization, and metastatic tumor formation. Each process is not only promoted by cancer cells themselves but is also affected by their microenvironment. Given this complexity, drug discovery for anti-metastatic drugs must consider the interaction between cancer cells and their microenvironments. The zebrafish is a suitable vertebrate animal model for in vivo high-throughput screening studies with physiological relevance to humans. This review covers the zebrafish model used to identify anti-metastatic drugs.

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http://dx.doi.org/10.3390/molecules25102407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287578PMC
May 2020

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