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Ann Behav Med 2022 Aug 16. Epub 2022 Aug 16.

Department of Kinesiology, The Pennsylvania State University, University Park, PA, USA.

Background: The COVID-19 pandemic adversely impacted physical activity, but little is known about how contextual changes following the pandemic declaration impacted either the dynamics of people's physical activity or their responses to micro-interventions for promoting physical activity.

Purpose: This paper explored the effect of the COVID-19 pandemic on the dynamics of physical activity responses to digital message interventions.

Methods: Insufficiently-active young adults (18-29 years; N = 22) were recruited from November 2019 to January 2020 and wore a Fitbit smartwatch for 6 months. Read More

Chemistry 2022 Aug 16. Epub 2022 Aug 16.

Royal Institute of Technology, Department of Chemistry, Teknikringen 30, 10044, Stockholm, SWEDEN.

Dynamic covalent polymers of different topology have been synthesized from an aromatic dialdehyde and α,ωdinitroalkanes via the nitroaldol reaction. All dinitroalkanes yielded dynamers with the dialdehyde, where the length of the dinitroalkane chain played a vital role in determining the structure of the final products. For longer dinitroalkanes, linear dynamers were produced, where the degree of polymerization reached a plateau at higher feed concentrations. Read More

Struct Chem 2022 Aug 11:1-33. Epub 2022 Aug 11.

Laboratory of Natural and Bioactive Substances, LASNABIO, University of Abou-BakrBelkaid, Tlemcen, Algeria.

In this paper, a data set of [H] diazepam derivatives was analyzed using various computational methods: molecular docking/dynamic simulations, and QSAR analysis. The main aims of these studies are to understand the binding mechanisms by which benzodiazepines allosterically modulate GABA receptor αβγ subtypes, from inducing neuronal inhibition at lower doses to the anesthetic effect at higher doses, and also, to define the structural requirements that contribute to improving the response of GABA/αβγ receptor to benzodiazepine drugs. The results of the molecular docking study allowed selecting Ro12-6377 and proflazepam as the best modulators for the four binding sites simultaneously. Read More

Microsurgery 2022 Aug 15. Epub 2022 Aug 15.

Department of Health Sciences and Medicine, University of Lucerne, Lucerne, Switzerland.

Preservation of laryngeal functions after supraglottic laryngectomy depends on both the extent of surgical resection and the type of reconstruction. Any reconstructive modality faces the challenges of preserving voice and swallow function due to the complex and dynamic anatomy of the larynx. In this report, we present a case in which the entire affected unilateral supraglottis and piriform sinus were functionally reconstructed using a triple chimeric superficial circumflex iliac artery perforator (SCIP) free flap. Read More

Zebrafish 2022 Aug;19(4):119-130

Aquatic Germplasm and Genetic Resources Center, School of Renewable Natural Resources, Louisiana State University Agricultural Center, Baton Rouge, Louisiana, USA.

Motility is a widely available parameter that can be used to assess sperm quality of aquatic species. Sperm from fishes with external fertilization usually undergo a dynamic and short-lived period of motility after activation. The common practice of assigning a single value at an arbitrary peak of motility presents challenges for reproducibility, community-level standardization, and comparisons across studies. Read More