Ann Endocrinol (Paris) 2020 10 21;81(5):511-515. Epub 2020 May 21.
Service d'endocrinologie et maladies métaboliques, CHU de Larrey, 31059 Toulouse, France. Electronic address:
Bull Cancer 2021 Apr 2. Epub 2021 Apr 2.
Sainte-Catherine Institute, 250, chemin des baigne-pieds, 84000 Avignon, France.
Introduction: The addition of palbociclib to endocrine therapy has been shown to improve progression free survival in hormone receptor positive metastatic breast cancer patients. This cyclin CDK4/6 inhibitor could expose patients to a grade 3-4 hematological toxicity, leading to treatment discontinuation or treatment interruption that is potentially associated with a lack of efficiency. The aim of this study was to identify predictive factors of severe early hematotoxicity (ESHT). Read More
Int J Environ Res Public Health 2021 Mar 27;18(7). Epub 2021 Mar 27.
UMRESTTE, UMR T 9405, Université Lyon 1, Université Gustave Eiffel-IFSTTAR, Domaine Rockefeller, 8 Avenue Rockefeller, 69008 Lyon, France.
Studying the human health impacts of pesticides and their endocrine disruptor (ED) effects is a public health concern. The aim of this study is to identify phytopharmaceutical active substances (PAS) that are an ED or are toxic on endocrine glands (TEG), and to propose an ED/TEG effect indicator. Five international official databases were analyzed to identify the occurrence of health outcomes for 458 PAS. Read More
FASEB J 2021 May;35(5):e21400
IGF, Université de Montpellier, CNRS, INSERM, Montpellier, France.
Anterior pituitary endocrine cells that release hormones such as growth hormone and prolactin are excitable and fire action potentials. In these cells, several studies previously showed that extracellular sodium (Na ) removal resulted in a negative shift of the resting membrane potential (RMP) and a subsequent inhibition of the spontaneous firing of action potentials, suggesting the contribution of a Na background conductance. Here, we show that the Na leak channel NALCN conducts a Ca - Gd -sensitive and TTX-resistant Na background conductance in the GH cell line, a cell model of pituitary endocrine cells. Read More
Br J Surg 2021 Jan 24. Epub 2021 Jan 24.
Department of Hepatobiliary Surgery and Liver Transplantation, Hôpital de la Pitié Salpêtrière, Assistance Publique-Hopitaux de Paris and Sorbonne University, Paris, France.
Background: The relevance of laparoscopic resection of intrahepatic cholangiocarcinoma (ICC) remains debated. The aim of this study was to compare laparoscopic (LLR) and open (OLR) liver resection for ICC, with specific focus on textbook outcome and lymph node dissection (LND).Methods: Patients undergoing LLR or OLR for ICC were included from two French, nationwide hepatopancreatobiliary surveys undertaken between 2000 and 2017. Read More
J Clin Endocrinol Metab 2021 Mar 30. Epub 2021 Mar 30.
Endocrine oncology unit, Gustave Roussy, F-94805, Villejuif, France.
Context: Locally advanced pheochromocytoma (LAP) behavior remains unknown.Objective: To characterize this population and its recurrence-free survival (RFS).Design: A retrospective multicentric study run within the ENDOCAN-COMETE network and GTE from 2003 to 2018. Read More