Int J Dermatol 2020 Aug 9;59(8):1010-1012. Epub 2020 May 9.
Dermatology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal.
Anticancer Drugs 2021 Aug 3. Epub 2021 Aug 3.
Department of Medical Oncology, Azienda USL IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
To date, there are no standardized systemic treatment options for patients with metastatic pituitary carcinoma progressed to chemo and radiation therapy. Immune-checkpoint inhibitors (ICIs) have been successfully assessed in other solid malignancies and could be a concrete hope for these patients. We performed a critical review of the literature aimed to evaluate studies assessing ICIs in pituitary malignancies. Read More
J Chromatogr A 2021 Jul 22;1653:462422. Epub 2021 Jul 22.
Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu, 221004, China. Electronic address:
Gastric carcinoma is one of the most common and deadly forms of cancer. Early detection is critical for successful treatment of gastric cancer, and examination of BAs in urine may provide a critical diagnostic tool for identifying gastric cancer at stages when it can still be cured. Bile acids (BAs) are a crucial toxic factor correlated with the injury of gastric mucosa and as such, quantifying the amount of BA in patient's urine could provide a new means to quickly and non-invasively identify the presence of gastric cancer in the early stages. Read More
J Health Econ 2021 Jul 16;79:102495. Epub 2021 Jul 16.
Department of Economics, University of Central Florida, P.O. Box 161400, Orlando, FL 32816-1400, USA. Electronic address:
The time at which a rational patient chooses to undergo an elective medical procedure for a non-life-threatening ailment is contemplated. The resulting model is purposely uncomplicated but general, and accounts for several basic factors that might affect such a decision. One such factor is that a patient cannot know with certainty the degree to which the medical procedure will be successful. Read More
Int J Radiat Oncol Biol Phys 2021 Aug 1. Epub 2021 Aug 1.
Department of Radiation Oncology, University of Michigan Medical School and Rogel Cancer Center, Ann Arbor, MI, USA. Electronic address:
Combination therapies with agents targeting the DNA damage response (DDR) offer an opportunity to selectively enhance the therapeutic index of chemoradiation or eliminate chemotherapy altogether. The successful translation of DDR inhibitors to clinical use requires investigating both their direct actions as (chemo)radiosensitizers, and their potential to stimulate tumor immunogenicity. Beginning with high-throughput screening using both viability and DNA damage-reporter assays, followed by validation in 'gold standard' radiation colony forming assays and in vitro assessment of mechanistic effects on the DDR we describe proven strategies and methods leading to the clinical development of DDR inhibitors both with radiation alone and in combination with chemoradiation. Read More
Int J Radiat Oncol Biol Phys 2021 Sep;111(1):14-22
Collaboration for Cancer Outcomes, Research and Evaluation (CCORE), Ingham Institute for Applied Medical Research, UNSW Sydney, Liverpool, Australia; Liverpool and Macarthur Cancer Therapy Centres, Western Sydney University, Campbelltown, Australia; School of Public Health, Faculty of Medicine and Health, University of Sydney, Camperdown, Australia. Electronic address:
Purpose: Cambodia is a Southeast Asian low-middle-income country with a population of >15 million. In 2020, Cambodia was estimated to have 18,375 new diagnoses of cancer and 12,638 deaths attributable to cancer. Cambodia was estimated to have a deficit of 16 megavoltage machines in 2012. Read More