A syndrome associated with leakage of intravascular fluid into third space with the most significant findings of recurrent pericardial effusion and pleural effusions without a specific cause.
The diagnosis of systemic capillary leak syndrome or Clarkson's disease is usually many months or years after original presentation. The patients go through multiple admissions with life-threatening presentations such as cardiac tamponade before the diagnosis is made. Timely treatment for this autoimmune condition can result in significant improvements in patient's quality of life, but also prevent hospitalisations and reduce admission and unnecessary investigation costs.
This case report presents a case of real-world experience of a patient with multiple emergency admissions due to cardiac tamponade. Repeat drainage of effusions failed and only upon the diagnosis, and treatment with steroids-immunotherapy was the patient able to improve and do well more than a year into follow up. Dr Habib Khan, MD
Eur Heart J Case Rep 2020 Apr 17;4(2):1-5. Epub 2020 Feb 17.
Trent Cardiac Centre, Nottingham University Hospitals, City Hospital Campus, Hucknall Road, Nottingham NG51PB, UK.
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