Current Approaches for Combination Therapy of Cancer: The Role of Immunogenic Cell Death.

Cancers (Basel) 2020 Apr 23;12(4). Epub 2020 Apr 23.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz 5165665811, Iran.

Cell death resistance is a key feature of tumor cells. One of the main anticancer therapies is increasing the susceptibility of cells to death. Cancer cells have developed a capability of tumor immune escape. Hence, restoring the immunogenicity of cancer cells can be suggested as an effective approach against cancer. Accumulating evidence proposes that several anticancer agents provoke the release of danger-associated molecular patterns (DAMPs) that are determinants of immunogenicity and stimulate immunogenic cell death (ICD). It has been suggested that ICD inducers are two different types according to their various activities. Here, we review the well-characterized DAMPs and focus on the different types of ICD inducers and recent combination therapies that can augment the immunogenicity of cancer cells.

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Source
http://dx.doi.org/10.3390/cancers12041047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226590PMC
April 2020

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