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Syndromes with gingival fibromatosis: A systematic review.

Authors:
Cláudio Rodrigues Rezende Costa Shélida Vasconcelos Braz Isabela Porto de Toledo Hercilio Martelli-Júnior Juliana Forte Mazzeu Eliete Neves Silva Guerra Ricardo D Coletta Ana Carolina Acevedo

Oral Dis 2021 May 25;27(4):881-893. Epub 2020 May 25.

Laboratory of Oral Histopathology, Health Sciences Faculty, University of Brasília, Brasília, Brazil.

Objective: The aim of systematic review was to describe the phenotypes and molecular profiles of syndromes with gingival fibromatosis (GF).

Methods: A comprehensive search of PubMed, LILACS, Livivo, Scopus, and Web of Science was conducted using key terms relevant to the research questions and supplemented by a gray literature search. The Methodological Quality and Synthesis of Case Series and Case Reports in association with the Case Series and Prevalence Studies from the Joanna Briggs Institute critical appraisal tools were used for the risk of bias. We followed the PRISMA checklist guidelines.

Results: Eighty-four studies reporting GF as an oral manifestation of a syndrome were identified in this review. Enamel renal syndrome was the most frequently reported syndrome with GF, represented by 54 individuals in 19 studies, followed by Zimmermann-Laband syndrome with 24 individuals in 15 studies and Costello syndrome, which was presented in a case series study with 41 individuals. Among reported cases, other clinical manifestations such as hypertrichosis, ectopic gingival calcification, and cherubism were described.

Conclusions: The results emphasize the need of systematic oro-dental-facial phenotyping for future descriptions as well as further molecular analysis in order to better understand the occurrence of syndromic GF.

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http://dx.doi.org/10.1111/odi.13369DOI Listing
May 2021

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