Lancet 2020 05 22;395(10234):e76. Epub 2020 Apr 22.
Neurosurgery Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano 20143, Italy.
Neurol Sci 2021 Jul 22. Epub 2021 Jul 22.
Università Cattolica del Sacro Cuore, Rome, Italy.
Background: JAM3 gene, located on human chromosome 11q25, encodes a member of the junctional adhesion molecule (JAM) family. Mutations of this gene are associated with hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts (HDBSCC).Case Report: Herein, we present a newborn male with a prenatal suspicion of bilateral cataracts but without fetal ultrasound findings of cortical malformations. Read More
Pediatr Infect Dis J 2021 Jul 20. Epub 2021 Jul 20.
From the Department of Paediatrics Department of Neurosurgery Department for Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway Paediatric Research Group, Department of Clinical Medicine, UiT, The Arctic University of Norway, Tromsø, Norway.
We describe a newborn infant with hydrocephalus and a ventriculoperitoneal shunt infection caused by Brevibacterium casei. Essential for correct diagnosis was rapid species identification by matrix-assisted laser desorption/ionization time-of-flight, after initial report of coryneform bacteria. The patient responded well to vancomycin and rifampicin for 15 days. Read More
Dev Cogn Neurosci 2021 Jul 12;51:100987. Epub 2021 Jul 12.
Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia; Victorian Infant Brain Study (VIBeS), Murdoch Children's Research Institute, Melbourne, Australia. Electronic address:
Children born very preterm (VPT; <32 weeks' gestation) have alterations in brain white matter and poorer math ability than full-term (FT) peers. Diffusion-weighted magnetic resonance imaging studies suggest a link between white matter microstructure and math in VPT and FT children, although longitudinal studies using advanced modelling are lacking. In a prospective longitudinal cohort of VPT and FT children we used Fixel-Based Analysis to investigate associations between maturation of white matter fibre density (FD), fibre-bundle cross-section (FC), and combined fibre density and cross-section (FDC) and math computation ability at 7 (n = 136 VPT; n = 32 FT) and 13 (n = 130 VPT; n = 44 FT) years, as well as between change in white matter and math computation ability from 7 to 13 years (n = 103 VPT; n = 21 FT). Read More
Neuro Oncol 2021 Jul 17. Epub 2021 Jul 17.
Newcastle University Centre for Cancer, Translational & Clinical Research Institute, Faculty of Medical Sciences, Newcastle upon Tyne, UK.
Background: <5% of medulloblastoma patients survive following failure of contemporary radiation-based therapies. Understanding the molecular drivers of medulloblastoma relapse (rMB) will be essential to improve outcomes. Initial genome-wide investigations suggested significant genetic divergence of the relapsed disease. Read More
Clin Infect Dis 2021 Jul 14. Epub 2021 Jul 14.
Duke Human Vaccine Institute, Duke University, Durham, NC, USA.
Background: Placentally-transferred maternal IgG protects against pathogens in early life, yet vertically-transmitted infections can interfere with transplacental IgG transfer. Although human cytomegalovirus (HCMV) is the most common placentally-transmitted viral infection worldwide, the impact of congenital HCMV (cCMV) infection on transplacental IgG transfer has been underexplored.Methods: We evaluated total and antigen-specific maternal and cord blood IgG levels and transplacental IgG transfer efficiency in a U. Read More