J Child Adolesc Psychopharmacol 2020 06 20;30(5):345-346. Epub 2020 Apr 20.
Stanford PANS/Immune Behavioral Health Clinic, PANS Research Program at Lucile Packard Children's Hospital, Palo Alto, California, USA.
Dig Liver Dis 2021 May 26;53(5):545-557. Epub 2021 Mar 26.
Paediatric Liver, GI and Transplantation, ASST-Hospital Papa Giovanni XXIII, Piazza OMS1, Bergamo 24127, Italy.
Acute liver failure (ALF) is a clinical condition characterized by the abrupt onset of coagulopathy and biochemical evidence of hepatocellular injury, leading to rapid deterioration of liver cell function. In children, ALF has been characterized by raised transaminases, coagulopathy, and no known evidence of pre-existing chronic liver disease; unlike in adults, the presence of hepatic encephalopathy is not required to establish the diagnosis. Although rare, ALF has a high mortality rate without liver transplantation (LT). Read More
Int J Surg Case Rep 2021 Mar 9;80:105625. Epub 2021 Feb 9.
Department of Surgery, Dankook University College of Medicine, Cheonan, Republic of Korea.
Introduction: Gastric heterotopia rarely occurs in the small intestine beyond ligament of Treitz. Most cases of jejunal gastric heterotopia have been reported in children and young adults. Herein we report a case of jejunal gastric heterotopia presenting as a perforation peritonitis in a middle-aged adult. Read More
J Psychiatr Res 2021 03 21;135:270-278. Epub 2021 Jan 21.
Stanford PANS/Immune Behavioral Health Clinic and PANS Research Program at Lucile Packard Children's Hospital, Palo Alto, CA, USA; Division of Allergy, Immunology & Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA, USA.
Objective: To characterize drug tolerability in pediatric patients with an abrupt-onset of obsessive-compulsive disorder (OCD) meeting criteria for pediatric acute-onset neuropsychiatric syndrome (PANS).Methods: We reviewed charts of 188 consecutive patients with PANS seen in the PANS clinic, collecting starting, side effect, and tolerated doses, as well as side effect profile for each antidepressant and antipsychotic trial.Results: Of 188 included patients: 57% had trials of antidepressants and/or antipsychotics. Read More
Brain Dev 2021 May 21;43(5):644-651. Epub 2021 Jan 21.
Neonatal and Pediatric Intensive Care Unit, Department of Critical Care, IRCCS Giannina Gaslini, Genova, Italy.
Background: Pathogenic variants in the dynamin 1 like gene are related to abnormal mitochondrial dynamics and distributions and are associated to variable clinical phenotypes. A few patients harboring the p.Arg403Cys missense variant appears to be different from the classical, more severe phenotypes, showing sudden onset of drug resistant seizures after a previously normal or slightly delayed development. Read More
Brain Dev 2021 Apr 13;43(4):566-570. Epub 2021 Jan 13.
Department of Pediatrics, Osaka Medical College, Takatsuki, Osaka, Japan.
Background: Rapid-onset dystonia-parkinsonism (RDP) is a disease characterized by an abrupt onset of dystonia accompanied by signs of parkinsonism and prominent bulbar symptoms.Case Report: We describe a case of a female patient, born after normal delivery, but diagnosed with mild intellectual disability at age 7. She presented with an abrupt onset of upper limb dystonia and bradykinesia without tremor in parkinsonism, as well as dysarthria and dysphagia caused by prominent bulbar symptoms, at age 9. Read More