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Respir Med 2021 Mar 28;181:106377. Epub 2021 Mar 28.

Division of Respiratory Diseases, Department of Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium.

J Immunol 2021 Apr 9. Epub 2021 Apr 9.

The 6th Department of Pediatrics, Linyi People's Hospital, Linyi 276000, People's Republic of China

Asthma is a respiratory disease with a dramatically increasing incidence globally. The present study explored the roles of S-phase kinase-associated protein 2 (SKP2) and forkhead box O3 (FOXO3) in asthma and their involvement in the Krüppel-like factor 15-lipoprotein receptor-related protein 5 (KLF15-LRP5) axis. SKP2 expression in patients with asthma and OVA-induced asthmatic Sprague Dawley rats was detected by reverse transcription quantitative PCR and Western blot assays. Read More

BMJ Case Rep 2021 Apr 9;14(4). Epub 2021 Apr 9.

Otolaryngology, Guy's and St Thomas' Hospitals NHS Trust, London, UK.

Laryngeal aspergillosis is most commonly seen as a secondary infection that spreads from the lungs and tracheobronchial tree. Primary invasive aspergillosis of the larynx is rare and most likely seen in an immunocompromised patient. We present a case of a 59-year-old woman who presented with progressive dysphonia and subsequently acute stridor. Read More

Ann Vasc Surg 2021 Apr 6. Epub 2021 Apr 6.

Division of Vascular Surgery, Department of Surgery. Louisiana State University Medical Center, New Orleans, LA, USA.

A 38-year-old man presented to the emergency room in the trauma bay for multiple ballistic injuries to the right neck. He was hemodynamically stable, protecting his airway, and neurologically intact. Computed tomography angiography (CTA) revealed absent filling the right internal carotid artery from its origin to the circle of Willis, which was intact, as well as absent petrous carotid canal on the right. Read More

Pediatr Pulmonol 2021 Apr 9. Epub 2021 Apr 9.

Cincinnati Children's Hospital Medical Center, 3333 Burnett Ave, Cincinnati, OH, 45229.

While there is a very large focus on the abnormalities of parenchymal lung development and extensive efforts to minimize alveolar damage with "gentle ventilation" and non-invasive respiratory support for neonates with bronchopulmonary dysplasia (BPD), there is relatively little consideration for the implications of central airway disease in this patient population. There are significant changes in the structure and conformation of the central airway during the last half of gestation, and premature birth disrupts this natural developmental process. Arrest of maturation results in a smaller airway that is more compliant, easier to deform, and more susceptible to damage. Read More