J Cutan Med Surg 2020 Mar/Apr;24(2):199-200
54473 507266 Division of Dermatology, McGill University Health Centre, Montreal General Hospital, QC, Canada.
Pediatr Dermatol 2021 Apr 19. Epub 2021 Apr 19.
Department of Pathology and Laboratory Medicine, Children's Mercy Hospital, Kansas City, MO, USA.
Holocarboxylase deficiency (HLCSD) is caused by biallelic pathogenic variants in HLCS and is associated with poor feeding, emesis, lethargy, seizures, life-threatening metabolic acidosis, and hyperammonemia. Skin involvement in HLCSD is typically described as scaly, erythrodermic, seborrhea-like, or ichthyosiform, but there is a paucity of reports. We report three patients, including two siblings, with HLCSD and significant cutaneous manifestations including ichthyosiform dermatitis and a presentation with features of annular pustular psoriasis. Read More
J Rheumatol 2021 Apr 15. Epub 2021 Apr 15.
School of Medicine, University of Utah, Salt Lake City, Utah, United States of America; Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, United States of America; Wellcome Sanger Institute, University of Cambridge, Hinxton, United Kingdom. Address correspondence to Bing-Jian Feng, Mail: 30 N 1900 E, Department of Dermatology, Salt Lake City, UT 84108, USA. Email:
Objective: Delays in the diagnosis and treatment of psoriatic arthritis (PsA) are common. These delays contribute to impairments in quality of life and joint damage. This study aims to calculate the incidence rate of PsA over time and identify clinical features that may be used for PsA prediction in psoriasis patients. Read More
Lancet 2021 Apr;397(10281):1301-1315
St John's Institute of Dermatology, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Psoriasis is a common, chronic papulosquamous skin disease occurring worldwide, presenting at any age, and leading to a substantial burden for individuals and society. It is associated with several important medical conditions, including depression, psoriatic arthritis, and cardiometabolic syndrome. Its most common form, chronic plaque or psoriasis vulgaris, is a consequence of genetic susceptibility, particularly in the presence of the HLA-C*06:02 risk allele, and of environmental triggers such as streptococcal infection, stress, smoking, obesity, and alcohol consumption. Read More
BMJ Open 2021 Mar 30;11(3):e043666. Epub 2021 Mar 30.
Service de Dermatologie, Assistance Publique-Hôpitaux de Paris Hôpital Saint-Louis, Paris, France
Introduction: Generalized pustular psoriasis (GPP) is a rare, potentially life-threatening disease characterised by recurrent flares of widespread neutrophilic aseptic skin pustular eruption. Despite the availability of approved biologics for GPP in Japan, Taiwan and Thailand, associated evidence is largely based on uncontrolled studies in which acute flares were not directly assessed. Therefore, there is a high unmet need to investigate new rapid-acting effective treatments that resolve symptoms associated with acute GPP flares. Read More
Expert Rev Clin Pharmacol 2021 Mar 31. Epub 2021 Mar 31.
Service de Dermatologie et Médecine Vasculaire, Hôpital Victor Dupouy, 69 rue du Lieutenant-Colonel Prud'hon, 95100 Argenteuil, France.
Introduction: : Psoriasis affects about 0.5% of children and adolescents, it has a high impact of social life. Management can be difficult. Read More