#COVID-19 or SARS-CoV-2 differs in its protein sequence with other SARS coronavirus. The study shows how this new virus camouflages in human though its unique glycosylation of spike glycoprotein. The study also finds human CD26 as a new target for this coronavirus for cell adhesion & hijacking.
The COVID-19 pandemic across is the current public-health emergency around the globe and killed more than 35,000 people and nearly one-million people getting infected. It is important to know how this virus is camouflaged and attacks human cell for infection. Unravelling these molecular issues will abet in finding the bonafide therapeutics.
The recent outbreak of pneumonia-causing COVID-19 pandemic is an urgent global public health issue with an increase in mortality and morbidity. The structures of COVID-19 spike glycoprotein in both closed (ligand-free) and open (ligand-bound) conformation open the arena of viral infection. While designing antibodies, the glycosylation pattern of virus need to be considered or the antibodies are useless. The structural and molecular dynamic studies show new human target for this virus and abet in finding new therapeutic to block the interaction between the virus and human CD26 a key immunoregulatory factor for cell adhesion and virulence.Dr Vankadari Naveen, MS., MPhil., DCA., PhD,
Emerg Microbes Infect 2020 17;9(1):601-604. Epub 2020 Mar 17.
Monash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, Australia.
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