Mol Cell Oncol 2020 10;7(2):1707045. Epub 2020 Jan 10.
Department of Pathology, UT Southwestern Medical Center, Dallas, Texas, USA.
Hydroxylation is a post-translational modification affecting protein stability, activity or interactome. We identified adenylosuccinate lyase (ADSL) as a novel hydroxylation substrate in triple negative breast cancer. Hydroxylation affects ADSL enzymatic activity and, therefore, adenosine levels. Adenosine, in turn, favors the translation of cMYC, triggering its oncogenic downstream cascade.