Adenylosuccinate lyase hydroxylation contributes to triple negative breast cancer via the activation of cMYC.

Mol Cell Oncol 2020 10;7(2):1707045. Epub 2020 Jan 10.

Department of Pathology, UT Southwestern Medical Center, Dallas, Texas, USA.

Hydroxylation is a post-translational modification affecting protein stability, activity or interactome. We identified adenylosuccinate lyase (ADSL) as a novel hydroxylation substrate in triple negative breast cancer. Hydroxylation affects ADSL enzymatic activity and, therefore, adenosine levels. Adenosine, in turn, favors the translation of cMYC, triggering its oncogenic downstream cascade.

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Source
http://dx.doi.org/10.1080/23723556.2019.1707045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051151PMC
January 2020

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