Aging (Albany NY) 2020 Feb 10;12(4):4040. Epub 2020 Feb 10.
Department of Gynecology and Obstetrics, Wuhan Central Hospital, Wuhan 430014, China.
J Immunol 2022 02 26;208(4):941-954. Epub 2022 Jan 26.
Immune Cell Signalling Laboratory, The Francis Crick Institute, London, United Kingdom;
TPL-2 kinase plays an important role in innate immunity, activating ERK1/2 MAPKs in myeloid cells following TLR stimulation. We investigated how TPL-2 controls transcription in TLR4-stimulated mouse macrophages. TPL-2 activation of ERK1/2 regulated expression of genes encoding transcription factors, cytokines, chemokines, and signaling regulators. Read More
Oxid Med Cell Longev 2021 21;2021:2805576. Epub 2021 Dec 21.
Radiation Therapy Center, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi 830011, China.
In previous studies, we found that B7 homolog 3 (B7-H3) was highly expressed in lung adenocarcinoma (LUAD) and promoted epithelial-to-mesenchymal transition (EMT) of LUAD cells. However, the underlying molecular mechanism is unclear. This study is aimed at evaluating the role of Ets-like protein 1 (ELK1) as a transcriptional regulator of B7-H3 for mediating the development and progression of LUAD and We confirmed that ELK1 is highly expressed in LUAD and is associated with poor patient prognosis. Read More
Cell Death Dis 2021 11 27;12(12):1113. Epub 2021 Nov 27.
Department of Gastroenterology, Institute of Liver and Gastrointestinal Diseases, Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China.
Metastasis is the predominant reason for high mortality of hepatocellular carcinoma (HCC) patients. It is critical to explore the molecular mechanism underlying HCC metastasis. Here, we reported that transcription factor One Cut homeobox 2 (ONECUT2) functioned as an oncogene to facilitate HCC metastasis. Read More
Med Oncol 2021 Nov 24;39(1):15. Epub 2021 Nov 24.
Key Laboratory for Experimental Teratology of Ministry of Education, Department of Pathology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan Wen Hua Xi Road 44, Jinan, 250012, Shandong, China.
KIF26B is a member of the kinesin superfamily that is up-regulated in various tumors, including breast cancer (BC), which can promote tumor progression. This study aimed to investigate the potential function of KIF26B in BC, and the underlying mechanisms, focusing mainly on cell proliferation. KIF26B expression was examined in BC tissue samples obtained from 99 patients. Read More
Int J Biol Sci 2021 17;17(15):4285-4304. Epub 2021 Oct 17.
Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
Circular RNAs (circRNAs) is a novel class of non-coding RNAs resulting from the non-canonical splicing of linear pre-mRNAs. However, the role of circRNAs in gastric cancer (GC) remains indistinct. This study aims to explore their potential modulation in GC and its prognostic value. Read More