Am J Physiol Endocrinol Metab 2020 03;318(3):E313-E317
Department of Medical Biophysics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Canada.
Blood Adv 2021 Sep 20. Epub 2021 Sep 20.
University of Miami, Miami, Florida, United States.
Human Germinal Center Associated Lymphoma (HGAL) is an adaptor protein specifically expressed in germinal center lymphocytes. High expression of HGAL is a predictor of prolonged survival of Diffuse Large B-Cell (DLBCL) and classical Hodgkin lymphomas. Furthermore, HGAL expression is associated with early stage DLBCL, thus potentially limiting lymphoma dissemination. Read More
Pharm Dev Technol 2021 Sep 20:1-20. Epub 2021 Sep 20.
Zhejiang Provincial Laboratory of Experimental Animal's & Nonclinical Laboratory Studies, College of Pharmacy, Hangzhou Medical College, Hangzhou, China.
In this study, oridonin-loaded long-circulating liposomes ([email protected]) were prepared with the ethanol injection method. Its physicochemical properties and the morphology were characterized, and its stability and release profiles were evaluated. Furthermore, its antitumor effects were studied using two in vitro cell models of colon cancer and two tumor-bearing models in nude mice. Read More
J Control Release 2021 Sep 14. Epub 2021 Sep 14.
School of Pharmacy, The University of Auckland, Auckland, New Zealand. Electronic address:
In this paper, rectal absorption and tissue tolerance of amoxicillin sodium (AS) suppositories prepared in a hydrophilic base, polyethylene glycol (PEG) or lipophilic base, Suppocire® NA 15 (SNA 15), were investigated. Following in vitro characterization, including drug distribution in the suppository bases, drug-base interactions and drug release, pharmacokinetics were investigated in rabbits to determine absolute bioavailability (F) at two dose levels (100 mg and 200 mg). Both types of suppositories were found uniform in weight and content. Read More
Colloids Surf B Biointerfaces 2021 Sep 2;208:112096. Epub 2021 Sep 2.
School of Optometry and Vision, University of New South Wales, Sydney, New South Wales, 2052, Australia.
Ocular drug delivery using contact lenses may be able to substitute for eye drop therapy. However, issues with hydrophobic drugs (like bimatoprost that is used to treat glaucoma) such as low drug uptake using a simple soaking method into preformed contact lenses and alteration in the swelling and transmittance of lenses restricts the application for drug delivery. This research uses graphene oxide (GO) to control the release of bimatoprost from contact lenses along with improvements in the drug uptake, and lens swelling and transmittance. Read More
Biomed Res Int 2021 4;2021:6644630. Epub 2021 Sep 4.
Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.
The object of this study was to prepare binary and ternary solid dispersions of atorvastatin (ATR) by the melting method using PEGs and poloxamer 188 (P188) as the carriers, singly and in combination with each other. Dissolution behavior, solubility studies, X-ray diffractometry, differential scanning calorimetry, and Fourier transform infrared spectroscopy were studied. Furthermore, antihyperlipidemic activities of formulations were compared to each other by serum lipid analyses in hyperlipidemic rats. Read More