Trends and clinico-epidemiological features of human rabies cases in Bangladesh 2006-2018.

Authors:
Dr. Sumon Ghosh, DVM, MS
Dr. Sumon Ghosh, DVM, MS
International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b)
Senior Field Research Officer (Veterinarian)
o Avian Influenza Surveillance in Bangladesh (August 2014-Present) o Risk of AI virus for contaminating environment of live bird markets and potential association of cleaning and disinfection (January 2015-June 2015) o KAP Study on Rabies in Satkhira District of Bangladesh (April 2012-May 2012) o K
Dhaka | Bangladesh

Sci Rep 2020 02 12;10(1):2410. Epub 2020 Feb 12.

Disease Control Unit, Communicable Disease Control, Directorate General of Health Services, Ministry of Health and Family Welfare, Dhaka, Bangladesh.

Vaccinating dogs against rabies is an effective means of reducing human rabies. We subjected 1327 clinically diagnosed human rabies death and mass dog vaccination (MDV) data during 2006-2018 to quantify the impacts of MDV on human rabies incidence in Bangladesh and a subset of rabies death data (422) for clinico-epidemiological analysis. A positive and increasing trend of MDV (p = 0.01 and tau = 0.71) and a negative and declining trend (p < 0.001 and tau = -0.88) of human rabies cases (Correlation coefficient: -0.82) have been observed. Among 422 deaths, the majority (78%) of the victims sought treatment from traditional healers, and 12% received post-exposure prophylaxis (PEP). The mean incubation period of rabies in cases with exposure sites on the head & neck (35 days) was shorter than the upper limb (mean = 64 days, p = 0.02) and lower limb (mean = 89 days, p < 0.01). MDV has been found to be effective for reducing human rabies cases in Bangladesh. Creating awareness among the animal bite victims to stop reliance on traditional healers rather seeking PEP, addressing the role of traditional healers through awareness education programme with respect to the treatment of dog bites, ensuring availability of PEP, and continuing to scale up MDV may help to prevent human rabies deaths.

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http://dx.doi.org/10.1038/s41598-020-59109-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016137PMC
February 2020
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