NMR Relaxation Measurements on Complex Samples Based on Real-Time Pure Shift Techniques.

Molecules 2020 Jan 22;25(3). Epub 2020 Jan 22.

Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance,State Key Laboratory for Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen 361005, China.

Longitudinal spin-lattice relaxation () and transverse spin-spin relaxation () reveal valuable information for studying molecular dynamics in NMR applications. Accurate relaxation measurements from conventional 1D proton spectra are generally subject to challenges of spectral congestion caused by coupling splittings and spectral line broadenings due to magnetic field inhomogeneity. Here, we present an NMR relaxation method based on real-time pure shift techniques to overcome these two challenges and achieve accurate measurements of and relaxation times from complex samples that contain crowded NMR resonances even under inhomogeneous magnetic fields. Both theoretical analyses and detailed experiments are performed to demonstrate the effectiveness and ability of the proposed method for accurate relaxation measurements on complex samples and its practicability to non-ideal magnetic field conditions.

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Source
http://dx.doi.org/10.3390/molecules25030473DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037015PMC
January 2020

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