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Neurochem Int 2021 Mar 3:105007. Epub 2021 Mar 3.

Instituto de Fisiología Celular, Departamento de Neurodesarrollo y Fisiología, Universidad Autónoma de México, CDMX, México.

Diabetic retinopathy is the most common cause of vision loss among diabetic patients. Although hyperglycemia produces retinal oxidative stress in long-standing diabetes, the pathogenesis mechanism is unknown. The Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a central role in cell responses against oxidative damage. Read More

Ophthalmol Ther 2021 Mar 6. Epub 2021 Mar 6.

Department of Ophthalmology, University of Iowa Hospital and Clinics, Iowa City, IA, USA.

Tele-ophthalmology is a rapidly evolving and exciting field that has become increasingly relevant amidst the current global pandemic. With advancements in technology, many components of an evaluation previously possible only in an office setting are becoming possible remotely, paving the way for at-home visits. Examples of these technologies include measurement of visual acuity using smartphones, remote monitoring of intraocular pressure using self-administered tonometers or implantable sensors, and use of digitally acquired slit-lamp or smartphone images for diagnosis of anterior segment pathology. Read More

Graefes Arch Clin Exp Ophthalmol 2021 Mar 6. Epub 2021 Mar 6.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China.

Purpose: To compare the outcomes of macular buckling (MB) surgery between myopic foveal detachment (FD) eyes with and without ellipsoid zone (EZ) disruption.

Methods: A retrospective, case-control study. Forty-four consecutive eyes from 44 patients received MB surgery for myopic FD between November 2017 and January 2019 were included. Read More

Diabetes 2021 Mar 5. Epub 2021 Mar 5.

Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 20080, China

Diabetic retinopathy (DR) is the leading cause of acquired blindness in middle-aged people. The complex pathology of DR is difficult to dissect, given the convoluted cytoarchitecture of the retina. Here, we performed single-cell RNA sequencing (scRNA-seq) of retina from type 2 diabetic model induced in leptin receptor-deficient (db/db) and control db/m mice with the aim of elucidating the factors mediating the pathogenesis of DR. Read More

Life (Basel) 2021 Feb 27;11(3). Epub 2021 Feb 27.

Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, Spain.

Autophagy is a catabolic process that ensures homeostasis in the cells of our organism. It plays a crucial role in protecting eye cells against oxidative damage and external stress factors. Ocular pathologies of high incidence, such as age-related macular degeneration, cataracts, glaucoma, and diabetic retinopathy are of multifactorial origin and are associated with genetic, environmental factors, age, and oxidative stress, among others; the latter factor is one of the most influential in ocular diseases, directly affecting the processes of autophagy activity. Read More