Cost-Effectiveness Analysis of Direct-Acting Antiviral Agents for Occupational Hepatitis C Infections in Germany.

Int J Environ Res Public Health 2020 01 9;17(2). Epub 2020 Jan 9.

Competence Centre for Epidemiology and Health Services Research for Healthcare Professionals (CVcare), University Medical Centre Hamburg-Eppendorf (UKE), 20246 Hamburg, Germany.

Around 1% of the world's population is infected with hepatitis C. The introduction of new direct-acting antiviral agents (DAAs) in 2014 has substantially improved hepatitis C treatment outcomes. Our objective was to evaluate the long-term cost effectiveness of DAAs in health care personnel (HP) with confirmed occupational diseases in Germany. A standardised database from a German statutory accident insurance was used to analyse the cost-effectiveness ratio for the DAA regimen in comparison with interferon-based triple therapies. Taking account of the clinical progression of the disease, a Markov model was applied to perform a base case analysis for a period of 20 years. The robustness of the results was determined using a univariate deterministic sensitivity analysis. The results show that treatment with DAAs is more expensive, but also more effective than triple therapies. The model also revealed that the loss of 3.23 life years can be averted per patient over the 20 years. Compared to triple therapies, DAA treatment leads to a higher sustained virologic response (SVR). Although this results in a decrease of costs in the long term, e.g., pension payments, DAA therapy will cause greater expense in the future due to the high costs of the drugs.

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijerph17020440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013637PMC
January 2020

Publication Analysis

Top Keywords

triple therapies
12
direct-acting antiviral
8
antiviral agents
8
robustness determined
4
determined univariate
4
years robustness
4
period years
4
base case
4
case analysis
4
analysis period
4
deterministic sensitivity
4
daas expensive
4
expensive effective
4
effective triple
4
treatment daas
4
analysis treatment
4
perform base
4
sensitivity analysis
4
univariate deterministic
4
model applied
4

Similar Publications