Immune response resolution of cutaneous leishmaniasis

Áurea Gabriel, Ana Valério-Bolas, Joana Palma-Marques, Patrícia Mourata-Gonçalves, Pedro Ruas, Tatiana Dias-Guerreiro, Gabriela Santos-Gomes

Overview

This review focuses on immune responses to Leishmania in cutaneous form of the disease

Summary

This review is aimed at providing a comprehensive outline of the immune response displayed against cutaneous leishmaniasis (CL), the more common zoonotic infection caused by protozoan parasites of the genus Leishmania.

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Author Comments

MSc Aurea Gabriel, PhD Student Researcher
MSc Aurea Gabriel, PhD Student Researcher
Global Health and Tropical Medicine/IHMT
Lisbon | Portugal
The investment in CL additional studies is urgent and essential, underlying the factors regulating immune pathological responses, which are needed for the implementation of more efficient and integrated control strategies and therapeutics. These efforts are indispensable for the populations affected by the disease, which are in desperate need of affordable and effective alternatives to the available treatments that are associated with parasite resistance and severe toxic effects.MSc Aurea Gabriel, PhD Student Researcher

Resources

Cutaneous Leishmaniasis: The Complexity of Host's Effective Immune Response against a Polymorphic Parasitic Disease.

J Immunol Res 2019 1;2019:2603730. Epub 2019 Dec 1.

Global Health and Tropical Medicine (GHTM), Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), Rua da Junqueira 100, 1349-008 Lisboa, Portugal.

This review is aimed at providing a comprehensive outline of the immune response displayed against cutaneous leishmaniasis (CL), the more common zoonotic infection caused by protozoan parasites of the genus Although of polymorphic clinical presentation, classically CL is characterized by leishmaniotic lesions on the face and extremities of the patients, which can be ulcerative, and even after healing can lead to permanent injuries and disfigurement, affecting significantly their psychological, social, and economic well-being. According a report released by the World Health Organization, the disability-adjusted life years (DALYs) lost due to leishmaniasis are close to 2.4 million, annually there are 1.0-1.5 million new cases of CL, and a numerous population is at risk in the endemic areas. Despite its increasing worldwide incidence, it is one of the so-called neglected tropical diseases. Furthermore, this review provides an overview of the existing knowledge of the host innate and acquired immune response to cutaneous species of The use of animal models and of studies has improved the understanding of parasite-host interplay and the complexity of immune mechanisms involved. The importance of diagnosis accuracy associated with effective patient management in CL reduction is highlighted. However, the multiple factors involved in CL epizoology associated with the unavailability of vaccines or drugs to prevent infection make difficult to formulate an effective strategy for CL control.

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Source
http://dx.doi.org/10.1155/2019/2603730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6913332PMC
May 2020

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References

(Supplied by CrossRef)

2014

Journal of Vector Borne Diseases 2008

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