PLoS One 2013 16;8(9):e73857. Epub 2013 Sep 16.
Radiobiology Unit, Molecular and Cellular Biology expert group, Belgian Nuclear Research Centre, SCK•CEN, Mol, Belgium ; Laboratory of Biochemistry and Molecular Cytology, Department of Molecular Biotechnology, Ghent University, Ghent, Belgium.
One of the objectives of the current international space programmes is to investigate the possible effects of the space environment on the crew health. The aim of this work was to assess the particular effects of simulated microgravity on mature primary neuronal networks and specially their plasticity and connectivity. For this purpose, primary mouse neurons were first grown for 10 days as a dense network before being placed in the Random Positioning Machine (RPM), simulating microgravity. Read More