Potential microRNA-related targets in clearance pathways of amyloid-β: novel therapeutic approach for the treatment of Alzheimer's disease.

Cell Biosci 2019 12;9:91. Epub 2019 Nov 12.

1Department of Pharmaceutical Biotechnology, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.

Imbalance between amyloid-beta (Aβ) peptide synthesis and clearance results in Aβ deregulation. Failure to clear these peptides appears to cause the development of Alzheimer's disease (AD). In recent years, microRNAs have become established key regulators of biological processes that relate among others to the development and progression of neurodegenerative diseases, such as AD. This review article gives an overview on microRNAs that are involved in the Aβ cascade and discusses their inhibitory impact on their target mRNAs whose products participate in Aβ clearance. Understanding of the mechanism of microRNA in the associated signal pathways could identify novel therapeutic targets for the treatment of AD.

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13578-019-0354-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6852943PMC
November 2019

Publication Analysis

Top Keywords

novel therapeutic
8
alzheimer's disease
8
neurodegenerative diseases
4
diseases review
4
progression neurodegenerative
4
review article
4
article overview
4
involved aβ
4
micrornas involved
4
overview micrornas
4
development progression
4
relate development
4
years micrornas
4
disease years
4
development alzheimer's
4
appears development
4
micrornas established
4
established key
4
processes relate
4
biological processes
4

Similar Publications