Impact of Subclinical Rejection on Kidney Graft Function.

Transplant Proc 2019 Dec 13;51(10):3304-3308. Epub 2019 Nov 13.

Kent Hospital, Department of General Surgery, Izmir, Turkey.

Background: In kidney transplant recipients with borderline infiltration, protocol biopsy results demonstrated the relationship with chronic injury. The purpose of this study was to evaluate the effect of subclinical rejection (SCR) on 6-month protocol biopsy results in long-term renal function in renal transplant recipients with stable graft function.

Material And Methods: Transplant protocol biopsies performed in 45 patients with stable renal function were included in this study at 6 months. Biopsy specimens were evaluated for SCR. Study groups were divided into patients with and without SCR. Renal functions were compared with pathologic evaluation. The effect of immunosuppressive regimens on renal function were evaluated in patients with SCR RESULT: The median age of patients was 32 years (range, 18-64 years). The median follow-up was 56 months (range, 24-84 months). According to the 6-month protocol biopsy results, 20 of 45 patients (44.4%) met SCR criteria based on Banff 07 parameters. There was not a statistically significant difference in renal function with SCR.

Conclusion: The presence of SCR on the 6-month protocol biopsy results in renal transplant recipients with a stable graft function does not cause deterioration in the long-term graft function.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.transproceed.2019.08.036DOI Listing
December 2019

Publication Analysis

Top Keywords

protocol biopsy
16
renal function
16
6-month protocol
12
graft function
12
transplant recipients
12
scr 6-month
8
stable graft
8
subclinical rejection
8
renal transplant
8
recipients stable
8
patients scr
8
renal
7
function
7
scr
6
biopsy
5
patients
5
protocol
5
pathologic evaluation
4
regimens renal
4
scr result
4

Similar Publications