Acta Biomater 2017 01 18;48:258-269. Epub 2016 Oct 18.
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA; Department of Biomedical Engineering, Purdue School of Engineering & Technology, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA; Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA. Electronic address:
The complex network of biochemical and biophysical cues in the pancreatic desmoplasia not only presents challenges to the fundamental understanding of tumor progression, but also hinders the development of therapeutic strategies against pancreatic cancer. Residing in the desmoplasia, pancreatic stellate cells (PSCs) are the major stromal cells affecting the growth and metastasis of pancreatic cancer cells by means of paracrine effects and extracellular matrix protein deposition. PSCs remain in a quiescent/dormant state until they are 'activated' by various environmental cues. Read More