Morphological MRI phenotypes of multiple sclerosis differ in resting-state brain function.

Sci Rep 2019 Nov 7;9(1):16221. Epub 2019 Nov 7.

Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, Graz, Austria.

We aimed to assess differences in resting-state functional connectivity (FC) between distinct morphological MRI-phenotypes in multiple sclerosis (MS). Out of 180 MS patients, we identified those with high T2-hyperintense lesion load (T2-LL) and high normalized brain volume (NBV; a predominately white matter damage group, WMD; N = 37) and patients with low T2-LL and low NBV (N = 37; a predominately grey matter damage group; GMD). Independent component analysis of resting-state fMRI was used to test for differences in the sensorimotor network (SMN) between MS MRI-phenotypes and compared to 37 age-matched healthy controls (HC). The two MS groups did not differ regarding EDSS scores, disease duration and distribution of clinical phenotypes. WMD compared to GMD patients showed increased FC in all sub-units of the SMN (sex- and age-corrected). WMD patients had increased FC compared to HC and GMD patients in the central SMN (leg area). Only in the WMD group, higher EDSS scores and T2-LL correlated with decreased connectivity in SMN sub-units. MS patients with distinct morphological MRI-phenotypes also differ in brain function. The amount of focal white matter pathology but not global brain atrophy affects connectivity in the central SMN (leg area) of the SMN, consistent with the notion of a disconnection syndrome.

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-019-52757-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6838050PMC
November 2019

Publication Analysis

Top Keywords

morphological mri-phenotypes
8
brain function
8
damage group
8
matter damage
8
white matter
8
edss scores
8
distinct morphological
8
smn leg
8
leg area
8
compared gmd
8
gmd patients
8
patients increased
8
central smn
8
multiple sclerosis
8
smn
6
patients
6
scores disease
4
disease duration
4
phenotypes wmd
4
differ edss
4

References

(Supplied by CrossRef)

A Compston et al.
Lancet 2008

B Bielekova et al.
Neurology 2005

S Tauhid et al.
J. Neurol. Sci. 2014

CRG Guttmann et al.
Magn. Reson. Imaging 2006

C Louapre et al.
Mult. Scler. 2015

M Vaneckova et al.
Eur. Neurol. 2009

T. Uher et al.
European Journal of Neurology 2016

CC Hemond et al.
Neurol. Neuroimmunol. NeuroInflammation 2019

MM Schoonheim et al.
Neurology 2012

MA Rocca et al.
Acta Neurol. Scand. 2016

C. Enzinger et al.
Neurology 2012

Similar Publications