Cerebellar volume loss in radiologically isolated syndrome.

Mult Scler 2019 Nov 4:1352458519887346. Epub 2019 Nov 4.

Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA; Neuro-Immunology Division and USC Multiple Sclerosis Comprehensive Care Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Radiologically isolated syndrome (RIS), in which asymptomatic demyelinating-appearing lesions are detected incidentally on MRI, can be a pre-clinical form of multiple sclerosis (MS). In this study, we measured cerebellar volumes on 3D T1-weighted 3T MR images in 21 individuals with RIS and 38 age- and sex-matched healthy controls (HC). Normalized cerebellar white matter volume and the anterior cerebellar gray matter volume were significantly decreased in RIS compared to HC ( = 0.003 and  = 0.005, respectively). Our findings support reports of regional brain atrophy in RIS prior to the development of a seminal attack related to inflammatory demyelination.

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http://dx.doi.org/10.1177/1352458519887346DOI Listing
November 2019

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