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Comparative RNA-seq analysis aids in diagnosis of a rare pediatric tumor.

Authors:
Lauren M Sanders Arun Rangaswami Isabel Bjork Du Linh Lam Holly C Beale Ellen Towle Kephart Ann Durbin Katrina Learned Rob Currie A Geoffrey Lyle Jacob Pfeil Avanthi Tayi Shah Alex G Lee Stanley G Leung Inge H Behroozfard Marcus R Breese Jennifer Peralez Florette K Hazard Norman Lacayo Sheri L Spunt David Haussler Sofie R Salama E Alejandro Sweet-Cordero Olena M Vaske

Cold Spring Harb Mol Case Stud 2019 10 23;5(5). Epub 2019 Oct 23.

Department of Molecular, Cell and Developmental Biology, UC Santa Cruz Genomics Institute, Santa Cruz, California 95064, USA.

Gliomatosis peritonei is a rare pathologic finding that is associated with ovarian teratomas and malignant mixed germ cell tumors. The occurrence of gliomatosis as a mature glial implant can impart an improved prognosis to patients with immature ovarian teratoma, making prompt and accurate diagnosis important. We describe a case of recurrent immature teratoma in a 10-yr-old female patient, in which comparative analysis of the RNA sequencing gene expression data from the patient's tumor was used effectively to aid in the diagnosis of gliomatosis peritonei.

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http://dx.doi.org/10.1101/mcs.a004317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824255PMC
October 2019

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Tunical Gliomatosis: An Uncommon Histological Entity.

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Background: Gliomatosis peritonei (GP) is characterized by widespread implants of mature glial tissue in the peritoneum. It is most often associated with immature or mature ovarian teratomas. A 6-month old infant developed isolated gliomatosis involving the tunica vaginalis following excision of an immature sacrococcygeal teratoma in the neonatal period. Read More

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Pediatr Blood Cancer 2020 04 25;67(4):e28186. Epub 2020 Jan 25.

Institut d'Hemato-Oncologie Pediatrique, Lyon, France.

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Gynecol Oncol 2020 04 15;157(1):94-100. Epub 2020 Jan 15.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, People's Republic of China. Electronic address:

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Ci Ji Yi Xue Za Zhi 2019 Oct-Dec;31(4):289-291. Epub 2019 Sep 16.

Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital , Buddhist Tzu Chi Medical Foundation and Tzu Chi University, Hualien, Taiwan.

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September 2019
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