The present study was to investigate the neuroprotective role of syringic acid (SA, 25mg/kg/day) on the neurotoxicity and oxidative damage induced by deltamethrin (DTM, 1.28mg/kg/day during two months) in CA1/3 pyramidal neurons. Animals were divided into 4 groups (n=16/group) (250–270g) for control, DTM, SA and DTM+SA. DTM and SA were administered by oral gavage daily. Rats that were given sub-chronic DTM had revealed a significant increase in caspase-3 levels, impaired recognition memory, reduced antioxidant activity and enhanced free radicals in the hippocampus. The results showed that SA ameliorated neurobehavioral alterations, reduced reactive oxygen/nitrogen species, pyknosis in the CA1/3 and increased antioxidant enzyme activity.
Antioxidant SA treatment may inhibit the ROS/RNS-induced oxidative damage, apoptosis of CA1/3 pyramidal neurons and neurodegeneration No studies have investigated the neuroprotective role of SA treatment on memory or its neuroprotective effect against DTM neurotoxicity. Analysing the effect of SA on memory through different pathways may lead to new and alternative treatment.
SA had potential neuroprotective and therapeutic impacts against sub-chronic DTM exposure via its antioxidant and antiapoptotic efficacy. Therefore, it can be used as a neuroprotective natural plant-derived agent against DTM-induced neurotoxicity.Dr. erenogut, PhD
Neurotoxicol Teratol 2019 Nov - Dec;76:106839. Epub 2019 Oct 20.
Department of Histology and Embryology, School of Medicine, Akdeniz University, Antalya 07070, Turkey.
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