Protective effects of syringic acid on neurobehavioral deficits and hippocampal tissue damages induced by sub-chronic deltamethrin exposure.

Eren Ogut, Rahime Sekerci, Guven Akcay, Fatos Belgin Yildirim, Narin Derin, Mutay Aslan, Leyla Sati

Overview

The present study was to investigate the neuroprotective role of syringic acid (SA, 25mg/kg/day) on the neurotoxicity and oxidative damage induced by deltamethrin (DTM, 1.28mg/kg/day during two months) in CA1/3 pyramidal neurons. Animals were divided into 4 groups (n=16/group) (250–270g) for control, DTM, SA and DTM+SA. DTM and SA were administered by oral gavage daily. Rats that were given sub-chronic DTM had revealed a significant increase in caspase-3 levels, impaired recognition memory, reduced antioxidant activity and enhanced free radicals in the hippocampus. The results showed that SA ameliorated neurobehavioral alterations, reduced reactive oxygen/nitrogen species, pyknosis in the CA1/3 and increased antioxidant enzyme activity.

Summary

Antioxidant SA treatment may inhibit the ROS/RNS-induced oxidative damage, apoptosis of CA1/3 pyramidal neurons and neurodegeneration No studies have investigated the neuroprotective role of SA treatment on memory or its neuroprotective effect against DTM neurotoxicity. Analysing the effect of SA on memory through different pathways may lead to new and alternative treatment.

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Author Comments

Dr.  erenogut, PhD
Dr. erenogut, PhD
Department of Anatomy / Bahcesehir University School of Medicine
Asst. Prof.
Anatomy
Istanbul | Turkey
SA had potential neuroprotective and therapeutic impacts against sub-chronic DTM exposure via its antioxidant and antiapoptotic efficacy. Therefore, it can be used as a neuroprotective natural plant-derived agent against DTM-induced neurotoxicity.Dr. erenogut, PhD

Resources

Protective effects of syringic acid on neurobehavioral deficits and hippocampal tissue damages induced by sub-chronic deltamethrin exposure
https://www.sciencedirect.com/science/article/abs/pii/S0892036219300558?via%3Dihub
Protective effects of syringic acid on neurobehavioral deficits and hippocampal tissue damages induced by sub-chronic deltamethrin exposure
https://www.researchgate.net/publication/336683071_Protective_effects_of_syringic_acid_on_neurobehavioral_deficits_and_hippocampal_tissue_damages_induced_by_sub-chronic_deltamethrin_exposure
Protective effects of syringic acid on neurobehavioral deficits and hippocampal tissue damages induced by sub-chronic deltamethrin exposure
https://scholar.google.com.tr/citations?hl=tr&user=I-89agkAAAAJ

Protective effects of syringic acid on neurobehavioral deficits and hippocampal tissue damages induced by sub-chronic deltamethrin exposure.

Authors:
Dr.  erenogut, PhD
Dr. erenogut, PhD
Department of Anatomy / Bahcesehir University School of Medicine
Asst. Prof.
Anatomy
Istanbul | Turkey

Neurotoxicol Teratol 2019 Nov - Dec;76:106839. Epub 2019 Oct 20.

Department of Histology and Embryology, School of Medicine, Akdeniz University, Antalya 07070, Turkey.

Recent developments in the field of insecticide exposure have led to a renewed interest in alternative antioxidant therapy. The present study was to investigate the neuroprotective role of syringic acid (SA, 25?mg/kg/day) on the neurotoxicity and oxidative damage induced by deltamethrin (DTM, 1.28?mg/kg/day during two months) in CA1/3 pyramidal neurons. Animals were divided into 4 groups (n?=?16/group) (250-270?g) for control, DTM, SA and DTM?+?SA. DTM and SA were administered by oral gavage daily. Rats that were given sub-chronic DTM had revealed a significant increase in caspase-3 levels, impaired recognition memory, reduced antioxidant activity and enhanced free radicals in the hippocampus. The results showed that SA ameliorated neurobehavioral alterations, reduced reactive oxygen/nitrogen species, pyknosis in the CA1/3 and increased antioxidant enzyme activity. In conclusion, SA (25?mg/kg/day) had potential neuroprotective and therapeutic impacts against sub-chronic DTM exposure via its antioxidant and antiapoptotic efficacy. Therefore, it can be used as a neuroprotective natural plant-derived agent against DTM-induced neurotoxicity.

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Source
http://dx.doi.org/10.1016/j.ntt.2019.106839DOI Listing
May 2020
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