Search Our Scientific Publications & Authors

Publications
find publications by category +
Translate page:

Clinical and epidemiologic factors associated with breast cancer and its subtypes among Northeast Chinese women.

Authors:
Dong-Man Ye Qiang Li Tao Yu Hao-Tian Wang Ya-Hong Luo Wen-Qing Li

Cancer Med 2019 12 23;8(17):7431-7445. Epub 2019 Oct 23.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Cancer Epidemiology, Peking University Cancer Hospital & Institute, Beijing, P. R. China.

The incidence of breast cancer has increased dramatically in China. We evaluated the clinical and epidemiologic factors associated with breast cancer, and its stage in a case-control study of Northeast Chinese women. We also examined whether these factors were differentially distributed among molecular subtypes of breast cancer in a case-only analysis. We identified 1118 breast cancer patients and 2284 healthy women from Cancer Hospital of Medical University between January 2014 and December 2017. Logistic regression models were used to calculate the odds ratios (ORs) and corresponding 95% confidence intervals (CIs). We found that postmenopausal women had a decreased risk of breast cancer (multivariate-adjusted OR = 0.33, 95% CI:0.25-0.43), and tended to have breast cancer of human epidermal growth factor receptor 2 (HER2)-overexpressing (multivariate-adjusted OR = 2.99, 95% CI: 1.49-5.97) and triple-negative (multivariate-adjusted OR = 2.16, 95% CI: 1.02-4.56) subtypes, compared with the luminal B subtype. Women with history of abortion had an increased risk of breast cancer (multivariate-adjusted OR = 4.70, 95% CI: 3.60-6.14). Women with high breast density and high Breast Imaging Reporting and Data System (BIRADS) scores of lesions tended to have breast cancer of advanced stage, but were not differentially distributed among its molecular subtypes. In conclusion, postmenopausal women had decreased risk of breast cancer, and tended to have nonluminal subtype, while women with history of abortion had increased risk of breast cancer. Women with high breast density and BIRADS scores of lesions tended to have advanced stage breast cancer. We provide evidence on the epidemiologic factors for breast cancer and its subtypes, which may help with breast cancer risk stratification.

Download full-text PDF

 Source
http://dx.doi.org/10.1002/cam4.2589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885867PMC
December 2019

Publication Analysis

Top Keywords

breast cancer
56
breast
17
risk breast
16
cancer
15
epidemiologic factors
12
high breast
12
women
9
women decreased
8
scores lesions
8
birads scores
8
breast density
8
women high
8
differentially distributed
8
distributed molecular
8
increased risk
8
women history
8
abortion increased
8
history abortion
8
advanced stage
8
subtype women
8

Keyword Occurance

Similar Publications

FTO genotype was associated with breast cancer in HER2 negative patients.

Authors:
Fateme Montazeri Hossein Hatami Soroor Fathi Naeemeh Hasanpour Ardekanizadeh Fatemeh Bourbour Samira Rastgoo Fatemeh Shafiee Mohammad Esmail Akbari Maryam Gholamalizadeh Seyed Alireza Mosavi Jarrahi Saeid Doaei

Clin Nutr ESPEN 2022 Jun 1;49:495-498. Epub 2022 Mar 1.

Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Reproductive Health Research Center, Department of Obstetrics and Gynecology, School of Medicine, Al-Zahra Hospital, Guilan University of Medical Sciences, Rasht, Iran. Electronic address:

Background: The fat mass and obesity-associated (FTO) gene may influence the risk of breast cancer (BC). The single nucleotide polymorphisms (SNPs) of FTO gene may exert different impacts on different types of BC. In this study, we investigated the association between FTO SNP rs9939609 and the status of estrogen receptor (ER), progesterone receptor (PR), P53, and human epidermal growth factor receptor-2 (HER-2) in BC patients. Read More

View Article and Full-Text PDF
June 2022
Similar Publications

Urinary concentrations of phenols, oxidative stress biomarkers and thyroid cancer: Exploring associations and mediation effects.

Authors:
Pan-Pan Chen Pan Yang Chong Liu Yan-Ling Deng Qiong Luo Yu Miao Min Zhang Fei-Peng Cui Jia-Yue Zeng Tian Shi Ting-Ting Lu Da Chen Long-Qiang Wang Chun-Ping Liu Ming Jiang Qiang Zeng

J Environ Sci (China) 2022 Oct 16;120:30-40. Epub 2022 Jan 16.

Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 , China. Electronic address:

Phenols have been shown to influence the cellular proliferation and function of thyroid in experimental models. However, few human studies have investigated the association between phenol exposure and thyroid cancer, and the underlying mechanisms are also poorly understood. We conducted a case-control study by age- and sex-matching 143 thyroid cancer and 224 controls to investigate the associations between phenol exposures and the risk of thyroid cancer, and further to explore the mediating role of oxidative stress. Read More

View Article and Full-Text PDF
October 2022
Similar Publications

Triple-negative breast cancer prevalence in Africa: a systematic review and meta-analysis.

Authors:
Shawn M Hercules Meena Alnajar Chen Chen Stefan M Mladjenovic Bolade Ajarat Shipeolu Olga Perkovic Greg R Pond Lawrence Mbuagbaw Kim Rm Blenman Juliet M Daniel

BMJ Open 2022 May 27;12(5):e055735. Epub 2022 May 27.

Biology, McMaster University, Hamilton, Ontario, Canada

Objective: The aggressive triple-negative breast cancer (TNBC) subtype disproportionately affects women of African ancestry across the diaspora, but its frequency across Africa has not been widely studied. This study seeks to estimate the frequency of TNBC among African populations.

Design: Systematic review and meta-analysis using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework. Read More

View Article and Full-Text PDF
May 2022
Similar Publications

Nipple-sparing Mastectomy with Immediate Implant-based Reconstruction for Patients with Pure Ductal Carcinoma in Situ.

Authors:
Antônio Luiz Frasson Ana Beatriz Falcone Isabela Miranda Alessandra Borba Anton de Souza Betina Vollbrecht Fernanda Barbosa Mônica Adriana Rodriguez Martinez Frasson Martina Lichtenfels

Rev Bras Ginecol Obstet 2022 Apr 27;44(4):376-384. Epub 2022 May 27.

Mastology Service, Hospital São Lucas, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Objective:  The presence of an extensive intraductal component is associated to an increasing risk of relapse in the nipple-areola complex. The aim of the present study was to evaluate the outcomes of patients diagnosed with ductal carcinoma in situ (DCIS) who underwent nipple-sparing mastectomy (NSM) with immediate breast reconstruction using silicone implants.

Methods:  We retrospectively analyzed the postoperative complications and oncological safety of 67 breast cancer patients diagnosed with pure DCIS who underwent NSM with immediate breast reconstruction using silicone implants between 2004 and 2018. Read More

View Article and Full-Text PDF
April 2022
Similar Publications

Mitochondria transfer and transplantation in human health and diseases.

Authors:
Zi-Hao Wang Lu Chen Wei Li Lingchao Chen Yi-Ping Wang

Mitochondrion 2022 May 24. Epub 2022 May 24.

Fudan University Shanghai Cancer Center, Key Laboratory of Breast Cancer in Shanghai, Shanghai Key Laboratory of Radiation Oncology, Cancer Institute, and The Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai 20032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 20032, China; The International Co-laboratory of Medical Epigenetics and Metabolism, Ministry of Science and Technology, Shanghai 20032, China. Electronic address:

Mitochondria are dynamic organelles responsible for energy production and cell metabolism. Disorders in mitochondrial function impair tissue integrity and have been implicated in multiple human diseases. Rather than constrained in host cells, mitochondria were recently found to actively travel between cells through nanotubes or extracellular vesicles. Read More

View Article and Full-Text PDF
May 2022
Similar Publications
}