EpCAM Circulating Tumor Cells: Gold in the Waste.

Dis Markers 2019 17;2019:1718920. Epub 2019 Sep 17.

Department of Molecular Medicine, Sapienza University of Rome, 00161 Rome, Italy.

The CellSearch® system which is still considered the gold standard for the enumeration of circulating tumor cells (CTC) utilizes antibodies against the epithelial cell adhesion molecule (EpCAM) for CTC enrichment. Recently, CTC discarded by the CellSearch® system due to their low EpCAM expression have been isolated and analyzed. We here sought to discuss technical and biological issues concerning the isolation and characterization of EpCAM CTC, highlighting the enormous potential of this subpopulation discarded by CellSearch®, which might instead reveal an unexpected clinical significance in tumor types where CTC enumeration has never been validated for prognostic and predictive purpose.

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/1718920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766153PMC
September 2019

Publication Analysis

Top Keywords

tumor cells
8
cellsearch® system
8
circulating tumor
8
discarded cellsearch®
8
epcam ctc
8
ctc
5
epcam expression
4
enormous potential
4
epcam
4
expression isolated
4
clinical significance
4
significance tumor
4
low epcam
4
enrichment ctc
4
ctc enrichment
4
ctc discarded
4
isolated analyzed
4
system low
4
tumor types
4
sought discuss
4

References

(Supplied by CrossRef)

Similar Publications