Acta Oncol 2020 Mar 28;59(3):310-314. Epub 2019 Sep 28.
HYKS Cancer Center, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Cancer Treat Rev 2021 Jul 22;99:102261. Epub 2021 Jul 22.
IEO, European Institute of Oncology, IRCCS, Milan, Italy. Electronic address:
Background: Temozolomide (TEM) is an active treatment in metastatic neuroendocrine tumors (NETs). Patients affected by glioblastoma multiforme or advanced melanoma treated with TEM who have deficiency of O-methylguanine DNA methyltransferase (MGMT) have a better responses and survival. However, the predictive role of MGMT in patients with NETs treated with TEM is still debated. Read More
Diagn Cytopathol 2021 Jul 31. Epub 2021 Jul 31.
Department of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Nivolumab is commonly used as monotherapy or in combination therapy for management of locally advanced or metastatic melanoma; however, it is also associated with immunotherapy-related adverse events concerning for disease progression or tumor flare reaction. This report presents a case of a non-neoplastic pseudotumor of the lung initially mistaken for malignancy that occurred in a patient receiving adjuvant nivolumab therapy following complete resection of stage IIIB melanoma. The diagnosis was made by lung biopsy and confirmed by a wedge resection, with findings consistent with organizing pneumonia type of pulmonary inflammatory pseudotumor rather than malignancy. Read More
Adv Sci (Weinh) 2021 Jul 31:e2004721. Epub 2021 Jul 31.
Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, P. R. China.
Uveal melanoma (UM) is the most prevalent primary intraocular malignant tumor with a high lethal rate. Patients who undergo conventional enucleation treatments consistently suffer permanent blindness, facial defects, and mental disorders, therefore, novel therapeutic modalities are urgently required. Herein, an injectable and stimuli-responsive drug delivery antibacterial hydrogel ([email protected]@DC_AC50) is constructed via a facile grinding method that is inspired by the preparation process of traditional Chinese medicine. Read More
J Immunother Cancer 2021 Jul;9(7)
Internal Medicine, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
Background: Soft-tissue sarcomas (STS) in the extremities and trunk treated with standard-of-care preoperative external beam radiation therapy (EBRT) followed by surgical resection are associated with local and distant relapses. In preclinical studies, oncolytic virotherapy in sarcoma has demonstrated antitumor effects via direct intratumoral oncolysis and cytotoxic T-cell-mediated immune responses. Talimogene laherparepvec (TVEC) is a replication-competent, immune-enhanced, oncolytic herpes simplex virus type 1 engineered for intratumoral injection; it has been approved by the FDA for the treatment of locally advanced and metastatic melanoma. Read More
Case Rep Oncol Med 2021 15;2021:7406911. Epub 2021 Jul 15.
Department of Internal Medicine, State University of New York-Downstate Health Sciences University, Brooklyn, New York, USA 11203.
Immune checkpoint inhibitors have opened a new era in treating advanced malignancies, resulting in a rapid increase in utilization, given the remarkable clinical outcomes. The incidence of immune-related adverse events increased due to the immunologic effects of these therapeutic agents. However, immune-related renal adverse events remain low, representing only a small incidence of reported cases. Read More