Next-generation regulatory T cell therapy.

Authors:
Leonardo Ferreira, PhD
Leonardo Ferreira, PhD
UCSF
Immune tolerance
San Francisco, California | United States

Nat Rev Drug Discov 2019 Oct 20;18(10):749-769. Epub 2019 Sep 20.

Department of Surgery, University of California, San Francisco, San Francisco, CA, USA.

Regulatory T cells (T cells) are a small subset of immune cells that are dedicated to curbing excessive immune activation and maintaining immune homeostasis. Accordingly, deficiencies in T cell development or function result in uncontrolled immune responses and tissue destruction and can lead to inflammatory disorders such as graft-versus-host disease, transplant rejection and autoimmune diseases. As T cells deploy more than a dozen molecular mechanisms to suppress immune responses, they have potential as multifaceted adaptable smart therapeutics for treating inflammatory disorders. Indeed, early-phase clinical trials of T cell therapy have shown feasibility, tolerability and potential efficacy in these disease settings. In the meantime, progress in the development of chimeric antigen receptors and in genome editing (including the application of CRISPR-Cas9) over the past two decades has facilitated the genetic optimization of primary T cell therapy for cancer. These technologies are now being used to enhance the specificity and functionality of T cells. In this Review, we describe the key advances and prospects in designing and implementing T cell-based therapy in autoimmunity and transplantation.

Download full-text PDF

Source
http://www.nature.com/articles/s41573-019-0041-4
Publisher Site
http://dx.doi.org/10.1038/s41573-019-0041-4DOI Listing
October 2019
291 Reads
41.908 Impact Factor

Publication Analysis

Top Keywords

cell therapy
12
inflammatory disorders
8
immune responses
8
cells
5
immune
5
suppress immune
4
mechanisms suppress
4
molecular mechanisms
4
enhance specificity
4
responses potential
4
potential multifaceted
4
adaptable smart therapeutics
4
smart therapeutics treating
4
cancer technologies
4
multifaceted adaptable
4
dozen molecular
4
technologies enhance
4
specificity functionality
4
cells review
4
rejection autoimmune
4

References

(Supplied by CrossRef)

RK Gershon et al.
Immunology 1970

S Sakaguchi et al.
J. Immunol. 1995

ES Husebye et al.
N. Engl. J. Med. 2018

N Komatsu et al.
Nat. Med. 2014

X Zhou et al.
Nat. Immunol. 2009

AK Abbas et al.
Sci. Immunol. 2018

MY Fan et al.
Cell Rep. 2018

W Liu et al.
J. Exp. Med. 2006

N Seddiki et al.
J. Exp. Med. 2006

N Ohkura et al.
Immunity 2013

A Miller et al.
J. Exp. Med. 1991

Similar Publications