Prognostic Significance of Abdominal-to-Gluteofemoral Adipose Tissue Distribution in Patients with Breast Cancer.

J Clin Med 2019 Sep 1;8(9). Epub 2019 Sep 1.

Department of Nuclear Medicine, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan, Chungcheongnam-do 31151, Korea.

This study aimed to evaluate the association between abdominal-to-gluteofemoral adipose tissue (AT) distribution and recurrence-free survival (RFS) in breast cancer patients. Staging F-18 fluorodexoyglucose (FDG) positron emission tomography/computed tomography (PET/CT) images of 336 women with breast cancer were retrospectively analyzed. From CT images, the volume and CT-attenuation of visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (SAT), and gluteofemoral AT were measured and the ratio of abdomen-to-gluteofemoral AT volume (AG volume ratio) was calculated. The relationships between adipose tissue parameters and RFS were assessed. Through univariate analysis, abdominal SAT volume, gluteofemoral AT volume, and AG volume ratio were significantly associated with RFS. An increase in abdominal SAT volume and AG volume ratio were associated with an increased risk of recurrence, whereas increased gluteofemoral AT volume was associated with a decreased risk of recurrence. On multivariate analysis, abdominal SAT volume, gluteofemoral AT volume, and AG volume ratio were found to be significant predictors of RFS after adjusting for clinic-histological factors. Irrespective of obesity, patients with a high AG volume ratio showed a higher recurrence rate than those with a low AG volume ratio. Increased abdominal SAT volume and decreased gluteofemoral AT volume were related to poor RFS in breast cancer patients.

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm8091358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6781262PMC
September 2019

Publication Analysis

Top Keywords

volume ratio
24
adipose tissue
20
volume volume
16
gluteofemoral volume
16
volume
16
breast cancer
16
sat volume
16
abdominal sat
16
rfs breast
8
ratio associated
8
analysis abdominal
8
abdominal-to-gluteofemoral adipose
8
cancer patients
8
tissue distribution
8
risk recurrence
8
volume gluteofemoral
8
ratio
7
adipose
5
rfs
5
abdominal
5

References

(Supplied by CrossRef)

Similar Publications