aqueous extract improves insulin sensitivity and hepatic steatosis in rodent model of fructose-induced metabolic syndrome.

Arch Physiol Biochem 2019 Aug 29:1-10. Epub 2019 Aug 29.

Istituto di Chimica Biomolecolare del Consiglio Nazionale delle Ricerche (ICB-CNR) , Catania , Italy.

Fructose consumption is associated with the development of obesity and metabolic syndrome (MetS) in human and animal models. This study investigates the ability of an aqueous extract of Asso (AH) to ameliorate fructose-induced MetS in Male Wistar rats. AH extract at doses of 100, 200 and 400?mg/kg b.w./day was administered for six weeks to MetS animals. Liquid fructose (10% w/v) intake did not vary total animal body weight, whereas, it produced moderate hyperglycemia associated with metabolic and histological alterations. Treating MetS rats with AH extract improved insulin sensitivity, alleviated atherogenic dyslipidaemia and decreased lipid deposition in their hepatic tissues. Additionally, AH extract was found to raise GSH level and antioxidant enzymes (GPx, GST and CAT) activities in rat livers homogenates. The results here reported demonstrated, for the first time, that have therapeutic proprieties against fructose-induced MetS in rodent model.

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http://dx.doi.org/10.1080/13813455.2019.1659825DOI Listing
August 2019
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