Development of Leiomyosarcoma in a Patient Treated with Azathioprine.

S D Med 2019 May;72(5):214-216

Department of Family Medicine, University of South Dakota Sanford School of Medicine, Sioux Falls, South Dakota.

Cirrhosis resulting from autoimmune hepatitis is associated with an increased risk of hepatocellular carcinoma. A common treatment for autoimmune hepatitis, azathioprine, is also associated with the development of many other cancers, predominantly lymphomas. The strongest association is seen for post-transplant lymphoma and hepatosplenic T-cell lymphoma in Crohn's disease and ulcerative colitis patients; there is also an association with a variety of cutaneous malignancies. A relationship between azathioprine and sarcoma has not been demonstrated, though there have been sporadic case reports. We report here the development of leiomyosarcoma in a patient who was treated with azathioprine for autoimmune hepatitis without cirrhosis.

Download full-text PDF

Source
May 2019

Publication Analysis

Top Keywords

autoimmune hepatitis
12
treated azathioprine
8
development leiomyosarcoma
8
patient treated
8
leiomyosarcoma patient
8
cancers lymphomas
4
variety cutaneous
4
association variety
4
lymphomas strongest
4
cutaneous malignancies
4
malignancies relationship
4
hepatitis azathioprine
4
azathioprine associated
4
associated development
4
strongest association
4
development cancers
4
treatment autoimmune
4
hepatosplenic t-cell
4
t-cell lymphoma
4
disease ulcerative
4

Similar Publications