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Carbohydr Polym 2021 Jun 5;262:117910. Epub 2021 Mar 5.

Department of Chemical Engineering/Graduate School of Biochemical Engineering, Ming Chi University of Technology, New Taipei City, 243303, Taiwan. Electronic address:

N-[(2-hydroxyl-3-trimethylammonium) propyl] chitosan chloride (HTCC), which is a type of chitosan derivative with quaternary ammonium groups, possesses a higher antibacterial activity as compared to the pristine chitosan. The nanofiber membranes made of HTCC are attractive for applications demanding for antibacterial function. However, the hydrophilic nature of HTCC makes it unsuitable for electrospinning of nanofibers. Read More

Polymers (Basel) 2021 Mar 25;13(7). Epub 2021 Mar 25.

N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Kosygin St. 4, Moscow 119991, Russia.

In this work, we studied the photocatalytic activity of photosensitizers (PSs) of various natures solubilized with polyvinylpyrrolidone (PVP) and ternary block copolymer ethylene and propylene oxide Pluronic F127 (F127) in a model reaction of tryptophan photo-oxidation in water in the presence of chitosan (CT). Water-soluble compounds (dimegin and trisodium salt of chlorin e6 (Ce6)) and hydrophobic porphyrins (tetraphenylporphyrin (TPP) and its fluorine derivative (TPPF20)) were used as PSs. It was shown that the use of chitosan (Mw ~100 kDa) makes it possible to obtain a system whose activity is comparable to that of the photosensitizer-amphiphilic polymer systems. Read More

Drug Deliv Transl Res 2021 Apr 1. Epub 2021 Apr 1.

Center for Research in Molecular Medicine & Chronic Diseases (CIMUS), School of Pharmacy, Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Campus Vida, Santiago de Compostela, 15706, Spain.

In the last few decades, nanotechnology has emerged as an important tool aimed at enhancing the immune response against modern antigens. Nanocarriers designed specifically for this purpose have been shown to provide protection, stability, and controlled release properties to proteins, peptides, and polynucleotide-based antigens. Polysaccharides are particularly interesting biomaterials for the construction of these nanocarriers given their wide distribution among pathogens, which facilitates their recognition by antigen-presenting cells (APCs). Read More

Colloids Surf B Biointerfaces 2021 Mar 17;202:111693. Epub 2021 Mar 17.

Beijing Institute of Technology, Beijing, 100081, PR China. Electronic address:

To increase the solubility and the encapsulation of zinc phthalocyanine (ZnPc) photosensitizer for photodynamic therapy (PDT), a positively charged amphiphilic phosphonium chitosan nanomicelle with multi-benzene structure was developed, and its application to PDT was explored. N-acetyl-l-phenylalanine-(4-carboxybutyl) triphenylphosphonium bromide chitosan (CTPB-CS-NAP), a chitosan derivative with tunable amphiphilicity, was synthesized first. ZnPc was encapsulated in CTPB-CS-NAP at the critical micelle concentration (CMC) of 4. Read More

Spectrochim Acta A Mol Biomol Spectrosc 2021 Mar 19;255:119714. Epub 2021 Mar 19.

Chemistry Department, Faculty of Sciences, Arak University, Dr. Beheshti Ave., Arak 38156-88349, Iran. Electronic address:

Herein, a chitosan Schiff base sample (CSAN) was strategically designed and prepared via a two-step process. In the first step, an azo derivative of 1- naphthylamine namely, [2-hydroxy-5-(naphthalene-1-yldiazenyl) benzaldehyde] (HNDB) was synthesized as an aldehyde moiety. Then the condensation reaction of HNDB with chitosan afforded CSAN as the target product. Read More