Discovery of Lipid Peroxidation Inhibitors from Species Prioritized through Multivariate Data Analysis and Multi-Informative Molecular Networking.

Molecules 2019 Aug 17;24(16). Epub 2019 Aug 17.

Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000, Thailand.

A major goal in the discovery of bioactive natural products is to rapidly identify active compound(s) and dereplicate known molecules from complex biological extracts. The conventional bioassay-guided fractionation process can be time consuming and often requires multi-step procedures. Herein, we apply a metabolomic strategy merging multivariate data analysis and multi-informative molecular maps to rapidly prioritize bioactive molecules directly from crude plant extracts. The strategy was applied to 59 extracts of three species (, and ), which were profiled by UHPLC-HRMS and screened for anti-lipid peroxidation activity. Using this approach, six lipid peroxidation inhibitors ‒ of three spp. were discovered, three of them being new compounds: monnieraside IV (), monnieraside V () and monnieraside VI (). The results demonstrate that this combined approach could efficiently guide the discovery of new bioactive natural products. Furthermore, the approach allowed to evidence that main semi-quantitative changes in composition linked to the anti-lipid peroxidation activity were also correlated to seasonal effects notably for .

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Source
http://dx.doi.org/10.3390/molecules24162989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6719142PMC
August 2019

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