Osteoglycin and Bone-a Systematic Review.

Curr Osteoporos Rep 2019 Oct;17(5):250-255

Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark.

Purpose Of Review: Bone turnover is a regulated process. Osteoglycin is suggested to have an important impact on bone function but may also affect cardiovascular and metabolic functions. This review investigates the action of osteoglycin in bone as well as its potential endocrine effects.

Recent Findings: Osteoglycin is expressed by several tissues including bone and muscle. Some studies suggest that osteoglycin increases osteoblast differentiation whereas others suggest that osteoglycin decreases osteoblast differentiation. Thus, findings on the influence of osteoglycin in bone are conflicting. A recent study found increased bone mass in osteoglycin deficient mice. Another study reported that osteoglycin is a marker of low bone mineral density and vertebral fractures in women with type 2 diabetes. Furthermore, clinical studies link osteoglycin to insulin resistance and cardiovascular disease. Osteoglycin may be a novel marker of a muscle, pancreatic, and bone axis. However, current evidence is limited and further research investigating osteoglycin in both a pre-clinical and a clinical setting is needed.

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http://dx.doi.org/10.1007/s11914-019-00523-zDOI Listing
October 2019
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References

(Supplied by CrossRef)

S Westberg-Rasmussen et al.
Bone 2017

RV Iozzo et al.
J Biol Chem 1999

A Liberati et al.
BMJ 2009

AL Boskey et al.
Bonekey Rep 2013

PD Delmas et al.
Baillieres Clin Obstet Gynaecol 1991

P Garnero et al.
Curr Osteoporos Rep 2009

2013

Y Imai et al.
Physiol Rev 2013

WJ Boyle et al.
Nature 2003

AM Pierce et al.
Electron Microsc Rev 1991

A Neve et al.
Cell Tissue Res 2011

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