The Role of Deubiquitinases in Oncovirus and Host Interactions.

J Oncol 2019 18;2019:2128410. Epub 2019 Jul 18.

Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha 410078, China.

Infection-related cancer comprises one-sixth of the global cancer burden. Oncoviruses can directly or indirectly contribute to tumorigenesis. Ubiquitination is a dynamic and reversible posttranslational modification that participates in almost all cellular processes. Hijacking of the ubiquitin system by viruses continues to emerge as a central theme around the viral life cycle. Deubiquitinating enzymes (DUBs) maintain ubiquitin homeostasis by removing ubiquitin modifications from target proteins, thereby altering protein function, stability, and signaling pathways, as well as acting as key mediators between the virus and its host. In this review, we focus on the multiple functions of DUBs in RIG-I-like receptors (RLRs) and stimulator of interferon genes (STING)-mediated antiviral signaling pathways, oncoviruses regulation of NF-B activation, oncoviral life cycle, and the potential of DUB inhibitors as therapeutic strategies.

Download full-text PDF

Source
http://dx.doi.org/10.1155/2019/2128410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6668545PMC
July 2019

Publication Analysis

Top Keywords

life cycle
8
signaling pathways
8
emerge central
4
pathways well
4
continues emerge
4
genes sting-mediated
4
interferon genes
4
central theme
4
protein function
4
viral life
4
theme viral
4
viruses continues
4
host review
4
processes hijacking
4
multiple functions
4
cellular processes
4
focus multiple
4
hijacking ubiquitin
4
antiviral signaling
4
system viruses
4

References

(Supplied by CrossRef)

Nature 2014

Similar Publications