Number of antioxidants have been used to treat peripheral nerve injury. However, there are few definitive experimental studies of ozone therapy for peripheral nerve cut injury. We aimed to examine the effects of mild level ozone therapy on sciatic nerve regeneration. One hundred adult male Wistar albino rats were randomly divided into four groups: group 1 (n=20) no cut injury or therapy; group 2 (n=20) sham; group 3 (n=30) nerve cut injury, no therapy; group 4 (n=30) nerve cut injury and ozone therapy. Sciatic functional index (SFI) and withdrawal reflex (WDR) were measured for all groups before nerve cut, at postoperative day 1, and at weeks 2, 4, 6 and 8.
This is the first study to examine the impacts of ozone therapy on sciatic nerve cut injury. Our findings suggest that ozone therapy may be a safe alternative method and a new therapeutic agent for peripheral nerve cut injury.
Our functional, biochemical, and ultrastructural data showed that ozone therapy has positive and beneficial effects in treating sciatic nerve cut injury. We believe that ozone increased plasma antioxidant levels by triggering different biochemical pathways without causing peripheral nerve degeneration.Dr. erenogut, PhD
Kurume Med J 2020 Jan 8;65(4):137-144. Epub 2019 Aug 8.
Department of Histology and Embryology, Faculty of Medicine, Akdeniz University.
Download full-text PDF