Neuroprotective Effects of Ozone Therapy After Sciatic Nerve Cut Injury.

Eren Ogut, Fatos Belgin Yildirim, Levent Sarikcioglu, Mutay Aslan Aydin, Necdet Demir

Overview

Number of antioxidants have been used to treat peripheral nerve injury. However, there are few definitive experimental studies of ozone therapy for peripheral nerve cut injury. We aimed to examine the effects of mild level ozone therapy on sciatic nerve regeneration. One hundred adult male Wistar albino rats were randomly divided into four groups: group 1 (n=20) no cut injury or therapy; group 2 (n=20) sham; group 3 (n=30) nerve cut injury, no therapy; group 4 (n=30) nerve cut injury and ozone therapy. Sciatic functional index (SFI) and withdrawal reflex (WDR) were measured for all groups before nerve cut, at postoperative day 1, and at weeks 2, 4, 6 and 8.

Summary

This is the first study to examine the impacts of ozone therapy on sciatic nerve cut injury. Our findings suggest that ozone therapy may be a safe alternative method and a new therapeutic agent for peripheral nerve cut injury.

Author Comments

Dr.  erenogut, PhD
Dr. erenogut, PhD
Department of Anatomy / Bahcesehir University School of Medicine
Asst. Prof.
Anatomy
Istanbul | Turkey
Our functional, biochemical, and ultrastructural data showed that ozone therapy has positive and beneficial effects in treating sciatic nerve cut injury. We believe that ozone increased plasma antioxidant levels by triggering different biochemical pathways without causing peripheral nerve degeneration.Dr. erenogut, PhD

Resources

Neuroprotective Effects of Ozone Therapy After Sciatic Nerve Cut Injury
https://www.jstage.jst.go.jp/article/kurumemedj/65/4/65_MS654002/_pdf/-char/en
Neuroprotective Effects of Ozone Therapy After Sciatic Nerve Cut Injury
https://www.researchgate.net/profile/Eren_Ogut
Neuroprotective Effects of Ozone Therapy After Sciatic Nerve Cut Injury
https://scholar.google.com.tr/citations?hl=tr&user=I-89agkAAAAJ

Neuroprotective Effects of Ozone Therapy After Sciatic Nerve Cut Injury.

Authors:
Dr.  erenogut, PhD
Dr. erenogut, PhD
Department of Anatomy / Bahcesehir University School of Medicine
Asst. Prof.
Anatomy
Istanbul | Turkey

Kurume Med J 2020 Jan 8;65(4):137-144. Epub 2019 Aug 8.

Department of Histology and Embryology, Faculty of Medicine, Akdeniz University.

A number of antioxidants have been used to treat peripheral nerve injury. However, there are few definitive experimental studies of ozone therapy for peripheral nerve cut injury. We aimed to examine the effects of mild level ozone therapy on sciatic nerve regeneration. One hundred adult male Wistar albino rats were randomly divided into four groups: group 1 (n=20) no cut injury or therapy; group 2 (n=20) sham; group 3 (n=30) nerve cut injury, no therapy; group 4 (n=30) nerve cut injury and ozone therapy. Sciatic functional index (SFI) and withdrawal reflex (WDR) were measured for all groups before nerve cut, at postoperative day 1, and at weeks 2, 4, 6 and 8. More myelinated (M) nerve fibers were observed after nerve cut injury in the ozone-therapy group. Significant differences were seen in plasma SOD (superoxide dismutase), CAT (catalase) and GPx (glutathione peroxidase) activities (p<0.05), and significant functional improvement was observed at postoperative weeks 2 and 4 (p<0.05) after ozone treatment. This is the first study conducted for the purpose of examining the effects of ozone therapy on sciatic nerve cut injury.

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Source
http://dx.doi.org/10.2739/kurumemedj.MS654002DOI Listing
January 2020
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