Perspectives of individuals with multiple sclerosis on discontinuation of disease-modifying therapies.

Mult Scler 2019 Aug 1:1352458519867314. Epub 2019 Aug 1.

Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic, Cleveland, OH, USA.

Background: Therapeutic research in multiple sclerosis (MS) has focused on the development of treatments with little investigation regarding the possibility of discontinuation of disease-modifying therapies (DMTs).

Objective: To understand the opinion of individuals with MS concerning stopping DMTs and the factors that influence the decision-making process.

Methods: A mixed method approach was used starting with three focus groups from which a survey was developed. This survey was sent to 1000 participants in the North American Research Committee on Multiple Sclerosis registry who met inclusion criteria (age ⩾45 years; on most recent DMT for ⩾5 years). Descriptive analysis and structural equation modeling were used.

Results: Of 1000 participants receiving the survey, 377 provided complete responses and met inclusion criteria. Only 11.9% of participants reported that if their disease was considered stable, they would consider coming off medications. A high level of external locus of control in influential others such as physicians significantly decreased the likelihood of considering discontinuation.

Conclusions: Most individuals with MS report being unlikely to consider stopping MS therapy if their disease was considered "non-active." As the results of studies concerning DMT discontinuation are obtained, information from providers will be an important part of individuals' decision-making process.

Download full-text PDF

Source
http://dx.doi.org/10.1177/1352458519867314DOI Listing
August 2019
3 Reads

Publication Analysis

Top Keywords

multiple sclerosis
12
inclusion criteria
8
discontinuation disease-modifying
8
disease-modifying therapies
8
met inclusion
8
disease considered
8
1000 participants
8
modeling usedresults
4
377 provided
4
usedresults 1000
4
receiving survey
4
survey 377
4
participants receiving
4
provided complete
4
participants reported
4
reported disease
4
119% participants
4
criteria 119%
4
complete responses
4
responses met
4

References

(Supplied by CrossRef)

Birnbaum G. et al.
Neurology 2014

Patton MQ et al.
1990

Similar Publications