Entry of the bat influenza H17N10 virus into mammalian cells is enabled by the MHC class II HLA-DR receptor.

Nat Microbiol 2019 Jul 29. Epub 2019 Jul 29.

Viral Pseudotype Unit, Medway School of Pharmacy, University of Kent and University of Greenwich, Chatham, UK.

Haemagglutinin and neuraminidase surface glycoproteins of the bat influenza H17N10 virus neither bind to nor cleave sialic acid receptors, indicating that this virus employs cell entry mechanisms distinct from those of classical influenza A viruses. We observed that certain human haematopoietic cancer cell lines and canine MDCK II cells are susceptible to H17-pseudotyped viruses. We identified the human HLA-DR receptor as an entry mediator for H17 pseudotypes, suggesting that H17N10 possesses zoonotic potential.

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41564-019-0517-3DOI Listing
July 2019
125 Reads

Publication Analysis

Top Keywords

h17n10 virus
8
hla-dr receptor
8
bat influenza
8
influenza h17n10
8
observed human
4
lines canine
4
viruses observed
4
human haematopoietic
4
cell lines
4
influenza viruses
4
haematopoietic cancer
4
cancer cell
4
mechanisms distinct
4
indicating virus
4
receptors indicating
4
acid receptors
4
virus employs
4
employs cell
4
distinct classical
4
entry mechanisms
4

Altmetric Statistics

References

(Supplied by CrossRef)
Article in Proc. Natl Acad. Sci. USA
S Tong et al.
Proc. Natl Acad. Sci. USA 2012
Article in PLoS Pathog.
S Tong et al.
PLoS Pathog. 2013
Article in J. Gen. Virol.
K Ciminski et al.
J. Gen. Virol. 2017
Article in Nat. Rev. Microbiol.
JS Long et al.
Nat. Rev. Microbiol. 2019
Article in Cell Rep.
X Sun et al.
Cell Rep. 2013
Article in Proc. Natl Acad. Sci. USA
X Zhu et al.
Proc. Natl Acad. Sci. USA 2012
Article in Nat. Commun.
M Juozapaitis et al.
Nat. Commun. 2014
Article in Trends Microbiol.
Y Wu et al.
Trends Microbiol. 2014
Article in Virology
J Maruyama et al.
Virology 2016
Article in Proc. Natl Acad. Sci. USA
EA Moreira et al.
Proc. Natl Acad. Sci. USA 2016
Article in PLoS ONE
M Hoffmann et al.
PLoS ONE 2016

Similar Publications