The effect of human umbilical cord blood-derived mesenchymal stem cell media containing serum on recovery after laser treatment: A double-blinded, randomized, split-face controlled study.

J Cosmet Dermatol 2019 Jul 22. Epub 2019 Jul 22.

Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.

Background: Ablative CO2 fractional laser (AFL) is a common cosmetic procedure to improve skin laxity. However, due to prolonged downtime and the risk of postinflammatory hyperpigmentation, laser-assisted delivery of active ingredients as post-laser treatment has gained interest in past years. Among various active ingredients, human umbilical cord blood-derived mesenchymal stem cells (hUCBMSCs) can be a promising agent promoting skin regeneration.

Aims: We evaluated the efficacy and safety of a human cord blood cell-conditioned media containing serum and cream on patients who underwent AFL treatment. A randomized, investigator-blinded, prospective, split-face comparison study was conducted.

Materials And Methods: Twenty-three patients who underwent AFL on both cheeks applied a human umbilical cord blood-derived mesenchymal stem cell (hUCBMSC)-conditioned media containing cream with or without stem cell containing serum application. As a primary outcome measure, we evaluated the total area of microcrusts and post-treatment erythema using digital photographs. Additionally, skin biophysical parameters (corneometer, TEWL) and global improvement scores for skin texture were assessed.

Results: The area of total microcrusts was reduced in the study group which applied both serum and cream. The global improvement score of the post-treatment erythema was significantly reduced. Investigator-assessed global improvement scores were higher in the combination treatment group. Additionally, there was no adverse event, which was associated with the use of either hUCBMSCs containing serum or cream.

Conclusion: The application of human cord blood cell containing serum and cream resulted in accelerated wound healing and reduced post-treatment erythema, which effectively reduced recovery time after ablative laser treatment.

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocd.13063DOI Listing
July 2019
2 Reads

Publication Analysis

Top Keywords

mesenchymal stem
12
serum cream
12
stem cell
12
global improvement
12
post-treatment erythema
12
blood-derived mesenchymal
12
human umbilical
12
cord blood-derived
12
umbilical cord
12
cord blood
8
improvement scores
8
patients underwent
8
laser treatment
8
active ingredients
8
human cord
8
cell serum
8
underwent afl
8
media serum
8
serum
6
human
5

References

(Supplied by CrossRef)
Multi‐center clinical study and review of fractional ablative CO2 laser resurfacing for the treatment of rhytides, photoaging, scars and striae
Alexiades‐Armenakas M et al.
J Drugs Dermatol 2011
Stem cells and the skin
Dahl MV et al.
J Cosmet Dermatol 2012
Mesenchymal stem cells in health and disease
Uccelli A et al.
Nat Rev Immunol 2008

Similar Publications