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Addict Biol 2022 Jul;27(4):e13179

Molecular Modeling and Biopharmaceutical Center, University of Kentucky, 789 South Limestone Street, Lexington, Kentucky, 40536, USA.

Dysregulation of dopamine transporters (DAT) within the dopaminergic system is an important biomarker of cocaine exposure. Depending on cocaine amount in-taken, one-time exposure in rats could lead to most (>95% of total) of DAT translocating to plasma membrane of the dopaminergic neurons compared to normal DAT distribution (~5.7% on the plasma membrane). Read More

Molecules 2022 Jun 8;27(12). Epub 2022 Jun 8.

Department of Biochemistry and Crop Quality, Institute of Soil Science and Plant Cultivation-State Research Institute, Czartoryskich 8, 24-100 Puławy, Poland.

contains a number of unusual polyphenols, derivatives of resveratrol and naringenin, called spiro-flavostilbenoids, which have potent in vitro anti-inflammatory, antioxidant, and moderate cholinesterase inhibitory activities. To date, these compounds have not been tested in vivo for the treatment of neurodegenerative diseases. The aim of the present study was to evaluate the effects of both single spiro-flavostilbenoids (yuccaol B and gloriosaol A) and phenolic fractions derived from bark on scopolamine-induced anxiety and memory process deterioration using a model. Read More

Ultrason Sonochem 2022 May 26;88:106048. Epub 2022 May 26.

Laboratory of Functional Foods and Nutraceuticals, Department of Food Science and Technology, University of Kashmir, Srinagar 190006, India.

Ginger (Zingiber officinale) and Licorice (Glycyrrhiza glabra L.) are one of the most popular spices having a wide range of bioactive compounds that have varied biological and pharmacological properties. The study was aimed to extract polyphenols from Himalayan medicinal herbs ginger and licorice in different solvents using ultra-sonication technique. Read More

J Ethnopharmacol 2022 Jun 15;296:115462. Epub 2022 Jun 15.

College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, 250355, Shandong Province, PR China. Electronic address:

Ethnopharmacological Relevance: Tapinanthus species are hemiparasites that grow on diverse hosts in African regions. Tapinanthus species are locally known as "all purpose herbs" as they are traditionally used to treat various diseases such as diabetes, hypertension, cancer, inflammation, malaria, anemia, anxiety, itching, and so on.

Aim Of The Study: A comprehensive review on research outcomes and future perspectives of Tapinanthus species are presented to provide a reference for relevant researchers. Read More

Plants (Basel) 2022 Jun 3;11(11). Epub 2022 Jun 3.

UMRt BioEcoAgro 1158-INRAE, BIOPI, Université de Picardie Jules Verne, 1 Rue des Louvels, F-80000 Amiens, France.

Mildbr bark is widely used in Gabonese folk medicine. However, little is known about the active compounds associated with its biological activities. In the present study, phytochemical profiling of the ethanolic extract of was performed using a de-replication strategy by coupling HPLC-ESI-Q/TOF with a molecular network approach. Read More