Sci Data 2019 06 20;6(1):98. Epub 2019 Jun 20.
UC Santa Cruz, 1156 High Street, Mailstop: Genomics Institute, Santa Cruz, CA, 95064, USA.
Blood 2021 Mar 8. Epub 2021 Mar 8.
Brigham and Women's Hospital, Harvard Medical School; Cancer Program, Broad Institute of MIT and Harvard, United States.
Inhibitors of Bruton's tyrosine kinase (BTKi) and phosphatidylinositol 3-kinase delta (PI3Kδi) that target the B cell receptor (BCR) signaling pathway have revolutionized the treatment of chronic lymphocytic leukemia (CLL). While mutations associated with resistance to BTK inhibitors have been identified, limited data are available on mechanisms of resistance to PI3Kδi. Here we present findings from longitudinal whole-exome sequencing of multiply relapsed CLL patients (Ncases=28) enrolled in PI3Ki trials. Read More
Leuk Res 2021 Mar 2;104:106554. Epub 2021 Mar 2.
School of Engineering and Sciences, Tecnologico de Monterrey, Av. Eugenio Garza Sada 2501 Sur, Tecnológico, 64849, Monterrey, NL, Mexico.
Lymphoma is a heterogeneous group of malignancies, which comprises 4.2 % of all new cancer cases and 3.3 % of all cancer deaths in 2019, globally. Read More
Contemp Clin Trials 2021 Mar 5:106347. Epub 2021 Mar 5.
Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Australia; School of Public Health, The University of Queensland, Brisbane, Australia.
Background: The D-Health Trial aims to determine whether monthly high-dose vitamin D supplementation can reduce the mortality rate and prevent cancer. We did not have adequate statistical power for subgroup analyses, so could not justify the high cost of collecting blood samples at baseline. To enable future exploratory analyses stratified by baseline vitamin D status, we developed models to predict baseline serum 25 hydroxy vitamin D [25(OH)D] concentration. Read More
J Am Acad Dermatol 2021 Mar 5. Epub 2021 Mar 5.
Dr. Philip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida. Electronic address:
J Pediatr 2021 Mar 5. Epub 2021 Mar 5.
Department of Public Health Sciences, University of California, Davis; Kaiser Permanente Washington Health Research Institute, Kaiser Permanente Washington. Electronic address:
Objective: To assess leukemia risks among children with Down syndrome in a large, contemporary cohort.Study Design: Retrospective cohort study including 3,905,399 children born 1996-2016 in seven U.S. Read More