Epigenetic Modification in Macrophages: A Promising Target for Tumor and Inflammation-associated Disease Therapy.

Curr Top Med Chem 2019 ;19(15):1350-1362

School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.

Macrophages are essential for supporting tissue homeostasis, regulating immune response, and promoting tumor progression. Due to its heterogeneity, macrophages have different phenotypes and functions in various tissues and diseases. It is becoming clear that epigenetic modification playing an essential role in determining the biological behavior of cells. In particular, changes of DNA methylation, histone methylation and acetylation regulated by the corresponding epigenetic enzymes, can directly control macrophages differentiation and change their functions under different conditions. In addition, epigenetic enzymes also have become anti-tumor targets, such as HDAC, LSD1, DNMT, and so on. In this review, we presented an overview of the latest progress in the study of macrophages phenotype and function regulated by epigenetic modifications, including DNA methylation and histone modifications, to better understand how epigenetic modification controls macrophages phenotype and function in inflammation-associated diseases, and the application prospect in anti-tumor.

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http://dx.doi.org/10.2174/1568026619666190619143706DOI Listing
October 2019
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References

(Supplied by CrossRef)

Gautier E.L. et al.
Nat Immunol 2012

Schulz C. et al.
Science 2012

Ginhoux F. et al.
Science 2010

Gordon S. et al.
Immunol Rev 2014

Yanez D.A. et al.
Pflugers Arch 2017

Calderon B. et al.
J Exp Med 2015

Dos Anjos C.A. et al.
Results Probl Cell Differ 2017

Dixon L.J. et al.
Compr Physiol 2013

Sasaki A. et al.
Neuropathology 2017

Hoeffel G. et al.
J Exp Med 2012

Gentek R. et al.
Immunol Rev 2014

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