Peripheral trauma and risk of dystonia: What are the evidences and potential co-risk factors from a population insurance database?

PLoS One 2019 10;14(5):e0216772. Epub 2019 May 10.

Department of Neurology, China Medical University Hospital, Taichung City, Taiwan.

Background: Dystonia is a neurological syndrome typically resulting in abnormal postures.

Objectives: We tested the role of physical injury as potential risk factor for development of dystonia using The National Health Insurance Research Database of Taiwan.

Methods: We identified 65704 people who were coded in the database as having had peripheral traumatic injuries (ICD-9-CM 807-848 and 860-959) in the year 2000. Patients with traumatic brain or spine injuries were excluded from analysis. We matched them using purposive sampling with 65704 people in the database who had not suffered peripheral trauma. We looked then at the incidence of dystonia occurring at least 1 year from the date of the peripheral trauma until 2011. Psychiatric symptoms (depression and anxiety) and sleeps difficulties have been investigated as potential covariates.

Results: We found 189 patients with dystonia (0.28%) in the trauma group, and 52 patients with dystonia (0.08%) in the non-trauma group. Trauma was independently associated with dystonia (adjusted HR = 3.12, 95% CI = 2.30-4.24). The incidence density of dystonia in the trauma group was 2.27 per 10000 person-years, while it was 0.71 per 10000 person-years in the non-trauma group Beyond the peripheral trauma, other variables associated to the incidence of dystonia included female sex, aged 40 years and above, depression and sleep disorders.

Conclusion: These data from a large population dataset support traumatic injury as a risk factor for the development of dystonia.

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0216772PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510449PMC
May 2019
3 Reads

Publication Analysis

Top Keywords

peripheral trauma
16
dystonia
10
65704 people
8
factor development
8
incidence dystonia
8
development dystonia
8
trauma group
8
10000 person-years
8
non-trauma group
8
risk factor
8
patients dystonia
8
trauma
6
peripheral
5
looked incidence
4
dystonia evidences
4
trauma looked
4
variables associated
4
suffered peripheral
4
trauma variables
4
database suffered
4

References

(Supplied by CrossRef)
Movement disorders
S Fahn et al.
1987
Head trauma in primary cranial dystonias: a multicentre case-control study
D Martino et al.
J Neurol Neurosurg Psychiatry 2007
Posttraumatic dystonia
K Frei et al.
J Neurol Sci 2017
The causalgia-dystonia syndrome
KP Bhatia et al.
Brain 1993
Chapter 8 in "Dystonia and Dystonic Syndromes"
A Macerollo et al.
2015
Psychogenic dystonia: a review of 18 cases
AE Lang et al.
Can J Neurol Sci 1995

Similar Publications