circMAN1A2 could serve as a novel serum biomarker for malignant tumors.

Authors:
Chun-Mei Fan
Chun-Mei Fan
Fourth Military Medical University
China
Jin-Peng Wang
Jin-Peng Wang
the Second Hospital of Jilin University
China
Yan-Yan Tang
Yan-Yan Tang
University of South China
China
Jin Zhao
Jin Zhao
Shihezi University School of Medicine
China
Shu-yi He
Shu-yi He
College of Veterinary Medicine
Fang Xiong
Fang Xiong
Sichuan University
China
Can Guo
Can Guo
Sun Yat-sen University
China
Bo Xiang
Bo Xiang
Central South University
China

Cancer Sci 2019 May 2. Epub 2019 May 2.

NHC Key Laboratory of Carcinogenesis, Xiangya Hospital, Central South University, Changsha, China.

Novel diagnostic and prognostic biomarkers of cancers are needed to improve precision medicine. Circular RNAs act as important regulators in cancers at the transcriptional and posttranscriptional levels. The circular RNA circMAN1A2 is highly expressed in nasopharyngeal carcinoma according to our previous RNA sequencing data; however, the expression and functions of circMAN1A2 in cancers are still obscure. Therefore, in this study, we evaluated the expression of circMAN1A2 in the sera of patients with nasopharyngeal carcinoma and other malignant tumors and analyzed its correlations with clinical features and diagnostic values. The expression levels of circMAN1A2 were detected by quantitative real-time PCR, and the correlations of clinical features with circMAN1A2 expression were analyzed by χ tests. Receiver operating characteristic curves were used to evaluate the clinical applications of circMAN1A2. The results showed that circMAN1A2 was upregulated in nasopharyngeal carcinoma, oral cancer, thyroid cancer, ovarian cancer, and lung cancer, with areas under the curves of 0.911, 0.779, 0.734, 0.694, and 0.645, respectively, indicating the good diagnostic value of circMAN1A2. Overall, our findings suggested that circMAN1A2 could be a serum biomarker for malignant tumors, providing important insights into diagnostic approaches for malignant tumors. Further studies are needed to elucidate the mechanisms of circMAN1A2 in the pathogenesis of cancer.

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http://dx.doi.org/10.1111/cas.14034DOI Listing
May 2019
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(Supplied by CrossRef)
Overexpression long non‐coding RNA LINC00673 is associated with poor prognosis and promotes invasion and metastasis in tongue squamous cell carcinoma
Yu J et al.
Oncotarget 2017
Upregulation and hypomethylation of lncRNA AFAP1AS1 predicts a poor prognosis and promotes the migration and invasion of cervical cancer
Bo H et al.
Oncol Rep 2019

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