Anatomical and functional investigation of the marmoset default mode network.

Nat Commun 2019 04 29;10(1):1975. Epub 2019 Apr 29.

Cerebral Microcirculation Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA.

The default mode network (DMN) is associated with a wide range of brain functions. In humans, the DMN is marked by strong functional connectivity among three core regions: medial prefrontal cortex (mPFC), posterior parietal cortex (PPC), and the medial parietal and posterior cingulate cortex (PCC). Neuroimaging studies have shown that the DMN also exists in non-human primates, suggesting that it may be a conserved feature of the primate brain. Here, we found that, in common marmosets, the dorsolateral prefrontal cortex (dlPFC; peak at A8aD) has robust fMRI functional connectivity and reciprocal anatomical connections with the posterior DMN core regions (PPC and PCC), while the mPFC has weak connections with the posterior DMN core regions. This strong dlPFC but weak mPFC connectivity in marmoset differs markedly from the stereotypical DMN in humans. The mPFC may be involved in brain functions that are further developed in humans than in other primates.

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41467-019-09813-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6488610PMC
April 2019
1 Read

Publication Analysis

Top Keywords

core regions
12
brain functions
8
mode network
8
dmn core
8
functional connectivity
8
prefrontal cortex
8
default mode
8
posterior dmn
8
connections posterior
8
dmn
6
common marmosets
4
marmosets dorsolateral
4
brain common
4
feature primate
4
primate brain
4
developed humans
4
dorsolateral prefrontal
4
a8ad robust
4
peak a8ad
4
dlpfc peak
4

Altmetric Statistics

References

(Supplied by CrossRef)

ME Raichle et al.
Annu. Rev. Neurosci. 2015

RL Buckner et al.
Ann. N. Y. Acad. Sci. 2008

SJ Broyd et al.
Neurosci. Biobehav. Rev. 2009

SK Barks et al.
Cereb. Cortex 2013

JL Vincent et al.
Nature 2007

D Mantini et al.
J. Neurosci. 2011

AM Belcher et al.
J. Neurosci. 2013

AC Silva et al.
Dev. Neurobiol. 2017

JV Liu et al.
NeuroImage 2013

M Ghahremani et al.
Cereb. Cortex 2017

C Liu et al.
NeuroImage 2018

Similar Publications