Memory dysfunction is a well recognized clinical manifestation of many neurologic and neuropsychiatric disorders. However, the role of endogenous neurosteroids in these deficits has not been fully elucidated. We review the literature on this topic and provide a path forward for future research in this area. We also discuss the potential role of synthetic neuroactive steroids as therapeutics for these memory deficits.
This review explores the effects of endogenous and exogenously administered neuroactive steroids on neural networks across the life span in men and women. We synthesize the body of peer reviewed literature to reveal the unique and common pathways via which these naturally occurring neuromodulators alter memory function in normal subjects and in persons with neurologic and neuropsychiatric disorders. We discuss the potential role of using synthetic analogues of these neurosteroids as therapeutics for memory disorders.
Writing this article with my co-authors with whom I have long standing collaborations was a great pleasure.Dr. Marcia Ratner, PhD, DABT
Front Endocrinol (Lausanne) 2019 9;10:169. Epub 2019 Apr 9.
Laboratory of Molecular Neurobiology, Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, United States.
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